Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)
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- dc.contributor.author Maya-Enero, Silvia
- dc.contributor.author Fàbregas-Mitjans, Montserrat
- dc.contributor.author Llufriu-Marquès, Rosa Maria
- dc.contributor.author Candel-Pau, Júlia
- dc.contributor.author García García, Jordi
- dc.contributor.author López-Vílchez, María Ángeles
- dc.date.accessioned 2023-02-06T07:26:01Z
- dc.date.issued 2022
- dc.description.abstract It is necessary to treat neonatal pain because it may have short- and long-term adverse effects. Frenotomy is a painful procedure where sucking, a common strategy to relieve pain, cannot be used because the technique is performed on the tongue. In a previous randomized clinical trial, we demonstrated that inhaled lavender essential oil (LEO) reduced the signs of pain during neonatal frenotomy. We aimed to find out whether inhaled vanilla essential oil (VEO) is more effective in reducing pain during frenotomy than LEO. Randomized clinical trial with neonates who underwent a frenotomy for type 3 tongue-ties between May and October 2021. Pain was assessed using pre and post-procedure heart rate (HR) and oxygen saturation (SatO2), crying time, and NIPS score. Neonates were randomized into "experimental" and "control" group. In both groups, we performed swaddling, administered oral sucrose, and let the newborn suck for 2 min. We placed a gauze pad with one drop of LEO (control group) or of VEO (experimental group) under the neonate's nose for 2 min prior to and during the frenotomy. We enrolled 142 neonates (71 per group). Both groups showed similar NIPS scores (2.02 vs 2.38) and crying times (15.3 vs 18.7 s). We observed no differences in HR increase or in SatO2 decrease between both groups. We observed no side effects in either of the groups. Conclusions: we observed no appreciable difference between LEO and VEO; therefore, we cannot conclude which of them was more effective in treating pain in neonates who underwent a frenotomy.
- dc.format.mimetype application/pdf
- dc.identifier.citation Maya-Enero S, Fàbregas-Mitjans M, Llufriu-Marquès RM, Candel-Pau J, Garcia-Garcia J, López-Vílchez MÁ. Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824). Eur J Pediatr. 2022 Nov; 181(11): 3923-29. DOI: 10.1007/s00431-022-04608-3
- dc.identifier.doi http://dx.doi.org/10.1007/s00431-022-04608-3
- dc.identifier.issn 0340-6199
- dc.identifier.uri http://hdl.handle.net/10230/55616
- dc.language.iso eng
- dc.publisher Springer
- dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00431-022-04608-3.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Ankyloglossia
- dc.subject.keyword Aromatherapy
- dc.subject.keyword Frenotomy
- dc.subject.keyword Lavender
- dc.subject.keyword Neonatal pain
- dc.subject.keyword Neonate
- dc.subject.keyword Tongue-tie
- dc.subject.keyword Vanilla
- dc.title Comparison of the analgesic effect of inhaled lavender vs vanilla essential oil for neonatal frenotomy: a randomized clinical trial (NCT04867824)
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion