Ambient air temperature exposure and foetal size and growth in three European birth cohorts

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• dc.contributor.author Essers, Esmée
• dc.contributor.author Granés, Laura
• dc.contributor.author Delaney, Scott
• dc.contributor.author Ballester, Joan
• dc.contributor.author Santos, Susana
• dc.contributor.author Petricola, Sami
• dc.contributor.author Yang, Tiffany C.
• dc.contributor.author Fernández-Somoano, Ana
• dc.contributor.author Bereziartua, Ainhoa
• dc.contributor.author Ballester Díez, Ferran
• dc.contributor.author Tardón, Adonina
• dc.contributor.author Tardón, Adonina
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Lertxundi, Aitana
• dc.contributor.author McEachan, Rosemary R.C.
• dc.contributor.author El Marroun, Hanan
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Iñiguez, Carmen
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2024-07-05T06:56:23Z
• dc.date.available 2024-07-05T06:56:23Z
• dc.date.issued 2024
• dc.description.abstract Introduction: Ambient air temperature may affect birth outcomes adversely, but little is known about their impact on foetal growth throughout pregnancy. We evaluated the association between temperature exposure during pregnancy and foetal size and growth in three European birth cohorts. Methods: We studied 23,408 pregnant women from the English Born in Bradford cohort, Dutch Generation R Study, and Spanish INMA Project. Using the UrbClimTM model, weekly ambient air temperature exposure at 100x100m resolution at the mothers' residences during pregnancy was calculated. Estimated foetal weight, head circumference, and femur length at mid and late pregnancy and weight, head circumference, and length at birth were converted into standard deviation scores (SDS). Foetal growth from mid to late pregnancy was calculated (grams or centimetres/week). Cohort/region-specific distributed lag non-linear models were combined using a random-effects meta-analysis and results presented in reference to the median percentile of temperature (14 °C). Results: Weekly temperatures ranged from -5.6 (Bradford) to 30.3 °C (INMA-Sabadell). Cold and heat exposure during weeks 1-28 were associated with a smaller and larger head circumference in late pregnancy, respectively (e.g., for 9.5 °C: -1.6 SDS [95 %CI -2.0; -0.4] and for 20.0 °C: 1.8 SDS [0.7; 2.9]). A susceptibility period from weeks 1-7 was identified for cold exposure and a smaller head circumference at late pregnancy. Cold exposure was associated with a slower head circumference growth from mid to late pregnancy (for 5.5 °C: -0.1 cm/week [-0.2; -0.04]), with a susceptibility period from weeks 4-12. No associations that survived multiple testing correction were found for other foetal or any birth outcomes. Conclusions: Cumulative exposure to cold and heat during pregnancy was associated with changes in foetal head circumference throughout gestation, with susceptibility periods for cold during the first pregnancy trimester. No associations were found at birth, suggesting potential recovery. Future research should replicate this study across different climatic regions including varying temperature profiles.
• dc.description.sponsorship The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the Faculty of Social Sciences of the Erasmus University Rotterdam, the Municipal Health Service Rotterdam area, Rotterdam, the Rotterdam Homecare Foundation, Rotterdam, and the Stichting Trombosedienst & Artsenlaboratorium Rijnmond (STAR- MDC), Rotterdam. We gratefully acknowledge the contribution of children and parents, general practitioners, hospitals, midwives, and pharmacies in Rotterdam. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam; the Erasmus University Rotterdam; the Netherlands Organization for Health Research and Development (ZonMw); the Netherlands Organization for Scientific Research (NWO); and the Ministry of Health, Welfare and Sport. Susana Santos is supported by the European Union's Horizon Europe Research and Innovation Programme under the Marie Sklodowska-Curie Postdoctoral Fellowship Grant Agreement No. 101109136 (URBANE). Dr. Hanan El Marroun was supported by Stichting Volksbond Rotterdam, the Netherlands Organization for Scientific Research (NWO) Aspasia grant (No: 015.016.056), and the European Union's Horizon 2020 Research and Innovation Program (HappyMums, Grant Agreement No: 101057390). The INMA Project is funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, FIS-FEDER: PI03/1615, PI04/1509, PI04/2018, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/02647, PI09/00090, PI09/02311, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02187, PI13/02429, PI14/00891, PI14/01687, PI16/1288, PI17/00663, PI18/00909, PI18/01142, PI20/01695); from the UE (FP7-ENV-2011 cod 282,957 and HEALTH.2010.2.4.5–1); European Union’s Horizon 2020 research and innovation programme ATHLETE project (grant agreement 874583); from Miguel Servet-FEDER (CP11/00178, CP15/00025, and CPII16/00051, CPII18/00018); from Generalitat Valenciana: FISABIO (UGP 15–230, UGP-15–244, and UGP-15–249); from the Alicia Koplowitz Foundation 2017; from CIBERESP; from Fundación Cajastur and Universidad de Oviedo; from the Department of Health of the Basque Government (2005111093, 2009111069, 2,013,111,089 and 2015111065); from the Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221); annual agreements with the municipalities of the Gipuzkoa study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain); and from Generalitat de Catalunya-CIRIT 1999SGR 00241. We received funding from the Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (EST-18 RF-25), acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA Program. Laura Granés was funded by a Rio Hortega fellowship (CM22/00011) awarded by the Spanish Institute of Health Carlos III. Scott Delaney’s research contribution reported in this publication was supported by the National Institute of Environmental Health Sciences under Award Number R01ES034373 and by the National Institute on Aging under Award Number R01AG066793. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Joan Ballester acknowledges funding from the Spanish Ministry of Science and Innovation under grant agreement No RYC2018-025446-I (programme Ramón y Cajal).
• dc.format.mimetype application/pdf
• dc.identifier.citation Essers E, Granés L, Delaney S, Ballester J, Santos S, Petricola S, et al. Ambient air temperature exposure and foetal size and growth in three European birth cohorts. Environ Int. 2024 Apr;186:108619. DOI: 10.1016/j.envint.2024.108619
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.108619
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/60671
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2024 Apr;186:108619
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101109136
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057390
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Climate change
• dc.subject.keyword Cohort study
• dc.subject.keyword Environmental health
• dc.subject.keyword Foetal development
• dc.subject.keyword Pregnancy
• dc.title Ambient air temperature exposure and foetal size and growth in three European birth cohorts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion