Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation

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• dc.contributor.author Garcia-Herrera, Adriana
• dc.contributor.author Song, Joo Y.
• dc.contributor.author Chuang, Shih-Sung
• dc.contributor.author Villamor, Neus
• dc.contributor.author Colomo Saperas, Luis Alberto
• dc.contributor.author Pittaluga, Stefania
• dc.contributor.author Alvaro, Tomas
• dc.contributor.author Rozman, Maria
• dc.contributor.author Anda Gonzalez, Jazmin de
• dc.contributor.author Arrunategui, Ana Maria
• dc.contributor.author Fernandez, Eva
• dc.contributor.author Gonzalvo, Elena
• dc.contributor.author Estrach, Teresa
• dc.contributor.author Colomer Pujol, Dolors
• dc.contributor.author Raffeld, Mark
• dc.contributor.author Gaulard, Philippe
• dc.contributor.author Campo, Elias
• dc.contributor.author Jaffe, Elaine S.
• dc.contributor.author Martinez, Antonio
• dc.date.accessioned 2019-04-10T08:37:08Z
• dc.date.available 2019-04-10T08:37:08Z
• dc.date.issued 2011
• dc.description.abstract γδ T cells represent a minor T-cell subset that is mainly distributed in mucosal surfaces. Two distinct lymphomas derived from these cells have been recognized: hepatosplenic γδ T-cell lymphoma (HSTL) and primary cutaneous γδ T-cell lymphoma (PCGD-TCL). However, whether other anatomic sites may also be involved and whether they represent a spectrum of the same disease are not well studied. The lack of T-cell receptor (TCR)β expression has been used to infer a γδ origin when other methods are not available. We studied 35 T-cell tumors suspected to be γδ TCL using monoclonal antibodies reactive with TCR δ or γ in paraffin sections. We were able to confirm γδ chain expression in 22 of 35 cases. We identified 8 PCGD-TCLs, 6 HSTLs, and 8 γδ TCLs without hepatosplenic or cutaneous involvement involving mainly extranodal sites. Two such cases were classified as enteropathy-associated T-cell lymphoma, type II. The other γδ TCL presented in the intestine, lung, tongue, orbit, and lymph node. In addition, we observed 13 cases with mainly extranodal involvement that lacked any TCR expression ("TCR silent"). In all cases, a natural killer cell origin was excluded. In conclusion, the lack of TCRβ expression does not always predict γδ-T-cell derivation, as TCR silent cases may be found. The recognition of γδ TCL presenting in extranodal sites other than skin and liver/spleen expands the clinical spectrum of these tumors. However, non-HSTL γδ TCL do not seem to represent a single entity. The relationship of these tumors with either HSTL or PCGD-TCL requires further study.
• dc.description.sponsorship Supported by Instituto de Salud Carlos III, Fondo de Investigación Sanitaria) PI080095 (AM) and PI050458 (TE). The Spanish Comisión Interministerial de Ciencia y Tecnología (CICYT) SAF08-3630 (EC), Red Temática de Investigación Cooperativa del Cáncer (RTICC) RD06/0020/0039 (EC), AGH is a fellow supported by the Instituto de Salud Carlos III. This work was also supported by the Intramural Research Program of the Center for Cancer Research, National Cancer Institute
• dc.format.mimetype application/pdf
• dc.identifier.citation Garcia-Herrera A, Song JY, Chuang SS, Villamor N, Colomo L, Pittaluga S et al. Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011 Aug;35(8):1214-25. DOI: 10.1097/PAS.0b013e31822067d1
• dc.identifier.doi http://dx.doi.org/10.1097/PAS.0b013e31822067d1
• dc.identifier.issn 0147-5185
• dc.identifier.uri http://hdl.handle.net/10230/37082
• dc.language.iso eng
• dc.publisher Lippincott Williams & Wilkins
• dc.relation.ispartof The American Journal of Surgical Pathology. 2011 Aug;35(8):1214-25
• dc.rights © Lippincott Williams & Wilkins. This is a non-final version of an article published in final form in Garcia-Herrera A, Song JY, Chuang SS, Villamor N, Colomo L, Pittaluga S et al. Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011 Aug; 35(8): 1214-25. http://dx.doi.org/10.1097/PAS.0b013e31822067d1
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Limfomes
• dc.subject.other Receptors cel·lulars
• dc.subject.other Pell -- Càncer
• dc.subject.other Limfòcits
• dc.title Nonhepatosplenic γδ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion