The renin-angiotensin system: a possible new target for depression
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- dc.contributor.author Vian, Joãoca
- dc.contributor.author Pereira, Círiaca
- dc.contributor.author Chavarría Romero, Víctorca
- dc.contributor.author Köhler, Cristianoca
- dc.contributor.author Stubbs, Brendonca
- dc.contributor.author Quevedo, Joãoca
- dc.contributor.author Kim, Sung-Wanca
- dc.contributor.author Carvalho, André F.ca
- dc.contributor.author Berk, Michaelca
- dc.contributor.author Fernandes, Brisa S.ca
- dc.date.accessioned 2018-04-18T07:20:30Z
- dc.date.available 2018-04-18T07:20:30Z
- dc.date.issued 2017
- dc.description.abstract Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment.
- dc.format.mimetype application/pdf
- dc.identifier.citation Vian J, Pereira C, Chavarria V, Köhler C, Stubbs B, Quevedo J. et al. The renin-angiotensin system: a possible new target for depression. BMC Med. 2017 Aug 1;15(1):144. DOI: 10.1186/s12916-017-0916-3
- dc.identifier.doi http://dx.doi.org/10.1186/s12881-017-0485-5
- dc.identifier.issn 1741-7015
- dc.identifier.uri http://hdl.handle.net/10230/34385
- dc.language.iso eng
- dc.publisher BioMed Centralca
- dc.rights Copyright © The Author(s). 2017. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword ATR1
- dc.subject.keyword ATR2
- dc.subject.keyword Angiotensin
- dc.subject.keyword Angiotensin receptor blockers
- dc.subject.keyword Angiotensin-converting enzyme inhibitors
- dc.subject.keyword Depression
- dc.subject.keyword Inflammation
- dc.subject.keyword Psychiatry
- dc.subject.keyword Renin–angiotensin system
- dc.subject.other Depressió psíquica
- dc.subject.other Angiotensines
- dc.title The renin-angiotensin system: a possible new target for depressionca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion