Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals

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• dc.contributor.author de Mendoza, Alex
• dc.contributor.author Suga, Hiroshi
• dc.contributor.author Permanyer, Jon
• dc.contributor.author Irimia Martínez, Manuel
• dc.contributor.author Ruiz Trillo, Iñaki
• dc.date.accessioned 2023-12-12T06:36:41Z
• dc.date.available 2023-12-12T06:36:41Z
• dc.date.issued 2015
• dc.description.abstract Cell-type specification through differential genome regulation is a hallmark of complex multicellularity. However, it remains unclear how this process evolved during the transition from unicellular to multicellular organisms. To address this question, we investigated transcriptional dynamics in the ichthyosporean Creolimax fragrantissima, a relative of animals that undergoes coenocytic development. We find that Creolimax utilizes dynamic regulation of alternative splicing, long inter-genic non-coding RNAs and co-regulated gene modules associated with animal multicellularity in a cell-type specific manner. Moreover, our study suggests that the different cell types of the three closest animal relatives (ichthyosporeans, filastereans and choanoflagellates) are the product of lineage-specific innovations. Additionally, a proteomic survey of the secretome reveals adaptations to a fungal-like lifestyle. In summary, the diversity of cell types among protistan relatives of animals and their complex genome regulation demonstrates that the last unicellular ancestor of animals was already capable of elaborate specification of cell types.
• dc.description.sponsorship European Research Council ERC-2007-StG-206883 to Alex de Mendoza, Hiroshi Suga, Iñaki Ruiz-Trillo. Ministerio de Economía y Competitividad BFU-2011-23434 to Alex de Mendoza. European Research Council ERC-2012-Co-616960 Alex de Mendoza. Japan Society for the Promotion of Science Research Activity to Hiroshi Suga. Center for Genomic Regulation Core funding to Jon Permanyer, Manuel Irimia Hiroshi Suga, Iñaki Ruiz-Trillo.
• dc.format.mimetype application/pdf
• dc.identifier.citation de Mendoza A, Suga H, Permanyer J, Irimia M, Ruiz-Trillo I. Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals. eLife. 2015 Oct 14;4:e08904. DOI: 10.7554/eLife.08904
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.08904
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/58498
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.ispartof eLife. 2015 Oct 14;4:e08904
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/206883
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU-2011-23434
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/616960
• dc.rights © 2015, de Mendoza et al.This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Cèl·lules
• dc.subject.other Éssers vius
• dc.subject.other Fongs
• dc.title Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion