Regulation of gene transcription by Polycomb proteins
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- dc.contributor.author Aranda Aragón, Sergio
- dc.contributor.author Mas, Glòria
- dc.contributor.author Di Croce, Luciano
- dc.date.accessioned 2023-06-27T06:07:31Z
- dc.date.available 2023-06-27T06:07:31Z
- dc.date.issued 2015
- dc.description.abstract The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG has long been considered a paradigmatic model for epigenetic maintenance of gene transcription programs. Despite intensive research efforts to unveil the molecular mechanisms of action of PcG proteins, several fundamental questions remain unresolved: How many different PcG complexes exist in mammalian cells? How are PcG complexes targeted to specific loci? How does PcG regulate transcription? In this review, we discuss the diversity of PcG complexes in mammalian cells, examine newly identified modes of recruitment to chromatin, and highlight the latest insights into the molecular mechanisms underlying the function of PcGs in transcription regulation and three-dimensional chromatin conformation.
- dc.description.sponsorship We are indebted to L. Morey, P. Vizan, and M. Beringer for critical reading of the manuscript. We also thank all the members of Di Croce laboratory for helpful discussions. We thank V. A. Raker for author’s editing. We apologize to any colleagues whose work has not been cited due to space limitations. Funding: This work received the support of the Secretary for Universities and Research of the Ministry of Economy and Knowledge of the Government of Catalonia (to S.A. and G.M.), the Lady Tata Memorial Trust (to S.A.), and “Ia Convocatoria de Ayudas Fundación BBVA a Investigadores, Innovadores y Creadores Culturales” (to G.M.M.). This work in Di Croce’s laboratory is supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P), from AGAUR (Agència de Gestió d’Ajuts Universitaris i de Recerca), from La Marató TV3, from the Fundación Vencer El Cáncer (VEC), Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017” (SEV-2012-0208), and from the European Commission’s 7th Framework Program 4DCellFate (grant number 277899). Author contributions: S.A., G.M., and L.D.C. wrote the manuscript. Competing interests: The authors declare that they have no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.
- dc.format.mimetype application/pdf
- dc.identifier.citation Aranda S, Mas G, Di Croce L. Regulation of gene transcription by Polycomb proteins. Sci Adv. 2015 Dec 4;1(11):e1500737. DOI: 10.1126/sciadv.1500737
- dc.identifier.doi http://dx.doi.org/10.1126/sciadv.1500737
- dc.identifier.issn 2375-2548
- dc.identifier.uri http://hdl.handle.net/10230/57347
- dc.language.iso eng
- dc.publisher American Association for the Advancement of Science (AAAS)
- dc.relation.ispartof Science Advances. 2015 Dec 4;1(11):e1500737
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/277899
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-48926-P
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SEV-2012-0208
- dc.rights 2015 © The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. Distributed under a Creative Commons Attribution Non Commercial License 4.0 (CC BY-NC).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
- dc.subject.keyword Gene regulation
- dc.subject.keyword Chromatin
- dc.subject.keyword Epigenetics
- dc.title Regulation of gene transcription by Polycomb proteins
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion