Autoimmune diseases and low baseline IgE in chronic spontaneous urticaria: A clinical and therapeutic prospective analysis in real-life clinical practice
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Pesqué, David
- dc.contributor.author March-Rodríguez, Alvaro
- dc.contributor.author March-Rodríguez, Alvaro
- dc.contributor.author Curto Barredo, Laia
- dc.contributor.author Soto, Dulce
- dc.contributor.author Gimeno, Ramón
- dc.contributor.author Pujol Vallverdú, Ramon Maria
- dc.contributor.author Giménez Arnau, Anna Maria
- dc.date.accessioned 2024-05-21T06:24:16Z
- dc.date.available 2024-05-21T06:24:16Z
- dc.date.issued 2023
- dc.description.abstract Background: Autoimmunity contributes to the pathogenesis of chronic spontaneous urticaria (CSU). The subtyping of CSU has revealed an autoimmune form of CSU. Despite autoimmune diseases having been associated with CSU, there are few prospective studies that have evaluated the characteristics and biomarkers of patients with CSU and autoimmune disease in a real-life practice setting. Objective: To evaluate the presence of specific biomarkers for the presence of autoimmune disease in CSU and to analyze the clinical and therapeutic features of patients with CSU and autoimmune disease. Methods: The clinical, laboratory, and therapeutic features of patients with CSU at a tertiary-level center were prospectively collected. Data obtained were compared in function of the presence/absence of autoimmune disease and typified according to IgE levels. Results: Patients with CSU who had associated autoimmune disease corresponded to middle-aged women with a common pattern of blood test findings: both low baseline IgE and high-affinity receptor of IgE expression, basopenia, eosinopenia, higher baseline erythrocyte sedimentation rate and D-dimer, increased presence of antinuclear antibodies, IgG against thyroid peroxidase, and positive autologous serum skin test result. Total baseline IgE less than or equal to 43.8 IU/mL was both the optimal cutoff to predict autoimmune disease in the CSU cohort and a significant risk factor for the presence of autoimmune disease in the regression analysis. Conclusions: In real-life clinical practice, characteristics of patients with CSU and autoimmune disease share common features with type IIb autoimmune CSU. Total baseline IgE less than or equal to 43.8 IU/mL has been detected as a possible biomarker of autoimmune disease in patients with CSU.
- dc.format.mimetype application/pdf
- dc.identifier.citation Pesqué D, March-Rodríguez Á, Curto-Barredo L, Soto D, Gimeno R, Pujol RM, et al. Autoimmune diseases and low baseline IgE in chronic spontaneous urticaria: A clinical and therapeutic prospective analysis in real-life clinical practice. J Allergy Clin Immunol Pract. 2023 Dec;11(12):3763-71.e5. DOI: 10.1016/j.jaip.2023.09.002
- dc.identifier.doi http://dx.doi.org/10.1016/j.jaip.2023.09.002
- dc.identifier.issn 2213-2198
- dc.identifier.uri http://hdl.handle.net/10230/60195
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof J Allergy Clin Immunol Pract. 2023 Dec;11(12):3763-71.e5
- dc.rights © 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Autoimmune urticaria
- dc.subject.keyword Autoimmunity
- dc.subject.keyword Chronic
- dc.subject.keyword IgE
- dc.subject.keyword IgG anti-TPO
- dc.subject.keyword Urticaria
- dc.title Autoimmune diseases and low baseline IgE in chronic spontaneous urticaria: A clinical and therapeutic prospective analysis in real-life clinical practice
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion