Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

Burguera, Demián; Márquez, Yamile; Racioppi, Claudia; Permanyer, Jon; Torres Méndez, Antonio; Esposito, Rosaria; Albuixech Crespo, Beatriz; Fanlo, Lucía; D'Agostino, Ylenia; Gohr, André; Navas Pérez, Enrique; Riesgo, Ana; Cuomo, Claudia; Benvenuto, Giovanna; Christiaen, Lionel A.; Martí, Elisa; D'Aniello, Salvatore; Spagnuolo, Antonietta; Ristoratore, Filomena; Arnone, Maria Ina; García Fernàndez, Jordi; Irimia Martínez, Manuel

Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

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dc.contributor.author Burguera, Demiánca
dc.contributor.author Márquez, Yamileca
dc.contributor.author Racioppi, Claudiaca
dc.contributor.author Permanyer, Jonca
dc.contributor.author Torres Méndez, Antonioca
dc.contributor.author Esposito, Rosariaca
dc.contributor.author Albuixech Crespo, Beatrizca
dc.contributor.author Fanlo, Lucíaca
dc.contributor.author D'Agostino, Yleniaca
dc.contributor.author Gohr, Andréca
dc.contributor.author Navas Pérez, Enriqueca
dc.contributor.author Riesgo, Anaca
dc.contributor.author Cuomo, Claudiaca
dc.contributor.author Benvenuto, Giovannaca
dc.contributor.author Christiaen, Lionel A.ca
dc.contributor.author Martí, Elisaca
dc.contributor.author D'Aniello, Salvatoreca
dc.contributor.author Spagnuolo, Antoniettaca
dc.contributor.author Ristoratore, Filomenaca
dc.contributor.author Arnone, Maria Inaca
dc.contributor.author García Fernàndez, Jordica
dc.contributor.author Irimia Martínez, Manuelca
dc.date.accessioned 2018-06-22T07:39:14Z
dc.date.available 2018-06-22T07:39:14Z
dc.date.issued 2017
dc.description.abstract Epithelial-mesenchymal interactions are crucial for the development of numerous animal structures. Thus, unraveling how molecular tools are recruited in different lineages to control interplays between these tissues is key to understanding morphogenetic evolution. Here, we study Esrp genes, which regulate extensive splicing programs and are essential for mammalian organogenesis. We find that Esrp homologs have been independently recruited for the development of multiple structures across deuterostomes. Although Esrp is involved in a wide variety of ontogenetic processes, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-to-epithelial transitions in deuterostome ancestors. However, consistent with the extensive rewiring of Esrp-dependent splicing programs between phyla, most developmental defects observed in vertebrate mutants are related to other types of morphogenetic processes. This is likely connected to the origin of an event in Fgfr, which was recruited as an Esrp target in stem chordates and subsequently co-opted into the development of many novel traits in vertebrates.
dc.description.sponsorship This work has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No ERC-StG-LS2-637591 to M.I.), the Spanish Ministry of Economy and Competitiveness (grant BFU2014-58908P to J.G.-F, BFU2014-55076-P to M.I., and the 'Centro de Excelencia Severo Ochoa 2013-2017', SEV-2012-0208), and ICREA - Generalitat de Catalunya (Academia Prize to J.G.-F). We acknowledge the support of the CERCA Programme/Generalitat de Catalunya. D.B. held an APIF fellowship from University of Barcelona, Y.M. an EMBO Long Term postdoctoral fellowship (ALTF 1505-2015), C.R. an EMBO long-term fellowship (ALTF 1608-2014), ATM an FPI-SO fellowship.
dc.format.mimetype application/pdf
dc.identifier.citation Burguera D, Marquez Y, Racioppi C, Permanyer J, Torres-Méndez A, Esposito R et al. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Nat Commun. 2017 Nov 27;8(1):1799. DOI: 10.1038/s41467-017-01961-y
dc.identifier.doi http://dx.doi.org/10.1038/s41467-017-01961-y
dc.identifier.issn 2041-1723
dc.identifier.uri http://hdl.handle.net/10230/34949
dc.language.iso eng
dc.publisher Nature Publishing Groupca
dc.relation.ispartof Nature Communications. 2017 Nov 27;8(1):1799
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/637591
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-58908-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55076-P
dc.rights © The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Evolutionary developmental biology
dc.subject.keyword Transcriptomics
dc.subject.keyword Esrp genes
dc.title Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processesca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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