Prevalence of clozapine-induced sialorrhea and its effect on quality of life

Sanagustin, David; Martín Subero, Marta; Hogg, Bridget; Fortea, Lydia; Gardoki-Souto, Itxaso; Guinart, Dani; Roldán-Berengué, Maria; Angelats, M.; Cerro, L.; Navas, D.; Jiménez, J.D.; Ortiz, L.; Ros, R.; Polo, X.; Ventura, Y.; Contreras, J.; Moreno Alcázar, Ana; Pérez Solá, Victor; Amann, Benedikt Lorenz; Valiente Gómez, Alicia

Prevalence of clozapine-induced sialorrhea and its effect on quality of life

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dc.contributor.author Sanagustin, David
dc.contributor.author Martín Subero, Marta
dc.contributor.author Hogg, Bridget
dc.contributor.author Fortea, Lydia
dc.contributor.author Gardoki-Souto, Itxaso
dc.contributor.author Guinart, Dani
dc.contributor.author Roldán-Berengué, Maria
dc.contributor.author Angelats, M.
dc.contributor.author Cerro, L.
dc.contributor.author Navas, D.
dc.contributor.author Jiménez, J.D.
dc.contributor.author Ortiz, L.
dc.contributor.author Ros, R.
dc.contributor.author Polo, X.
dc.contributor.author Ventura, Y.
dc.contributor.author Contreras, J.
dc.contributor.author Moreno Alcázar, Ana
dc.contributor.author Pérez Solá, Victor
dc.contributor.author Amann, Benedikt Lorenz
dc.contributor.author Valiente Gómez, Alicia
dc.date.accessioned 2023-05-10T06:17:31Z
dc.date.issued 2023
dc.description.abstract Rationale: Clozapine has proven to be superior to other antipsychotic drugs in the treatment of schizophrenia but is under-prescribed due to its potentially severe side effects. Clozapine-induced sialorrhea (CIS) is a frequent and extremely uncomfortable side effect, which remains understudied. Objectives: To examine the prevalence of diurnal and nocturnal CIS in a sample of patients treated with clozapine, and to evaluate its impact on quality of life. Methods: We conducted a cross-sectional, observational study of 130 patients with schizophrenia spectrum disorders treated with clozapine. The prevalence of CIS was evaluated via specific sialorrhea scales. None of the patients included in the study was receiving a specific treatment for hypersalivation during the study period. Possible associations between sialorrhea and clinical and quality of life variables were analyzed. Results: Of 130 subjects, 120 (92.3%) suffered from CIS. Eighty-one (62.31%) suffered from diurnal CIS, 115 (88.56%) from nocturnal CIS, and 85 (65.38%) suffered from both. Significant positive associations between quality of life and diurnal CIS (B = 0.417; p = 2.1e - 6, R2 = 0.156) and nocturnal CIS (B = 0.411; p = 7.7e - 6, R2 = 0.139) were detected. Thirty per cent of the subjects reported a moderate to severe negative impact of sialorrhea on their quality of life. Conclusions: The present study suggests that CIS is highly prevalent in patients with schizophrenia and has an important impact on quality of life in one-third of our sample. Therefore, the inclusion of a systematic evaluation and treatment of CIS in standard clinical practice is highly recommended. Trial registration: Clinical Trials ( https://clinicaltrials.gov ) under reference NCT04197037.
dc.format.mimetype application/pdf
dc.identifier.citation Sanagustin D, Martin-Subero M, Hogg B, Fortea L, Gardoki I, Guinart D, Roldán M, Angelats M, Cerro L, Navas D, Jiménez JD, Ortiz L, Ros R, Polo X, Ventura Y, Contreras J, Moreno-Alcázar A, Pérez-Sola V, Amann BL, Valiente-Gómez A. Prevalence of clozapine-induced sialorrhea and its effect on quality of life. Psychopharmacology (Berl). 2023 Jan;240(1):203-11. DOI: 10.1007/s00213-022-06294-3
dc.identifier.doi http://dx.doi.org/10.1007/s00213-022-06294-3
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/56740
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology (Berl). 2023 Jan;240(1):203-11
dc.rights This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00213-022-06294-3
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.keyword Adverse drug reaction
dc.subject.keyword Clozapine
dc.subject.keyword Sialorrhea
dc.subject.keyword Treatment-resistant schizophrenia
dc.title Prevalence of clozapine-induced sialorrhea and its effect on quality of life
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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