Paternal and induced gut microbiota seeding complement mother-to-infant transmission

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  • dc.contributor.author Dubois, Léonard
  • dc.contributor.author Vallès Colomer, Mireia
  • dc.contributor.author Ponsero, Alise
  • dc.contributor.author Helve, Otto
  • dc.contributor.author Andersson, Sture
  • dc.contributor.author Kolho, Kaija-Leena
  • dc.contributor.author Asnicar, Francesco
  • dc.contributor.author Korpela, Katri
  • dc.contributor.author Salonen, Anne
  • dc.contributor.author Segata, Nicola
  • dc.contributor.author Vos, Willem M. de
  • dc.date.accessioned 2024-06-17T15:06:12Z
  • dc.date.available 2024-06-17T15:06:12Z
  • dc.date.issued 2024
  • dc.description.abstract Microbial colonization of the neonatal gut involves maternal seeding, which is partially disrupted in cesarean-born infants and after intrapartum antibiotic prophylaxis. However, other physically close individuals could complement such seeding. To assess the role of both parents and of induced seeding, we analyzed two longitudinal metagenomic datasets (health and early life microbiota [HELMi]: N = 74 infants, 398 samples, and SECFLOR: N = 7 infants, 35 samples) with cesarean-born infants who received maternal fecal microbiota transplantation (FMT). We found that the father constitutes a stable source of strains for the infant independently of the delivery mode, with the cumulative contribution becoming comparable to that of the mother after 1 year. Maternal FMT increased mother-infant strain sharing in cesarean-born infants, raising the average bacterial empirical growth rate while reducing pathogen colonization. Overall, our results indicate that maternal seeding is partly complemented by that of the father and support the potential of induced seeding to restore potential deviations in this process.
  • dc.description.sponsorship This work was partially supported by the Netherlands Organization for Scientific Research (NWO-SIAM gravitation grant 024.002.002) to W.M.d.V., Business Finland (grant 329/31/2015) to W.M.d.V. and A.S., the Academy of Finland (grants 339172 to A.J.P. and 1325103 to A.S.), the European Research Council (ERC-StG project MetaPG-716575 and ERC-CoG microTOUCH-101045015) to N.S., and EMBO ALTF 593–2020 to M.V.-C. The work was also partially supported by the European H2020 programme (ONCOBIOME-825410 project, MASTER-818368 project, and IHMCSA-964590) to N.S., by the National Cancer Institute of the National Institutes of Health (1U01CA230551) to N.S., and by the Premio Internazionale Lombardia e Ricerca 2019 to N.S. Open access funded by the Helsinki University Library.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Dubois L, Valles-Colomer M, Ponsero A, Helve O, Andersson S, Kolho KL, Asnicar F, Korpela K, Salonen A, Segata N, de Vos WM. Paternal and induced gut microbiota seeding complement mother-to-infant transmission. Cell Host Microbe. 2024 Jun 12;32(6):1011-1024.e4. DOI: 10.1016/j.chom.2024.05.004
  • dc.identifier.doi http://dx.doi.org/10.1016/j.chom.2024.05.004
  • dc.identifier.issn 1931-3128
  • dc.identifier.uri http://hdl.handle.net/10230/60495
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Cell Host Microbe. 2024 Jun 12;32(6):1011-1024.e4
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101045015
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825410
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/818368
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/964590
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/716575
  • dc.rights © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Early life
  • dc.subject.keyword Father-infant
  • dc.subject.keyword Fecal microbiota transplantation
  • dc.subject.keyword Maternal FMT
  • dc.subject.keyword Maternal transmission
  • dc.subject.keyword Microbiome seeding
  • dc.subject.keyword Microbiota
  • dc.subject.keyword Paternal transmission
  • dc.subject.keyword Strain sharing
  • dc.title Paternal and induced gut microbiota seeding complement mother-to-infant transmission
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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