IL18 signaling promotes homing of mature Tregs into the thymus
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- dc.contributor.author Peligero Cruz, Cristina, 1986-
- dc.contributor.author Givony, Tal
- dc.contributor.author Sebé-Pedrós, Arnau
- dc.contributor.author Dobeš, Jan
- dc.contributor.author Kadouri, Noam
- dc.contributor.author Nevo, Shir
- dc.contributor.author Roncato, Francesco
- dc.contributor.author Alon, Ronen
- dc.contributor.author Goldfarb, Yael
- dc.contributor.author Abramson, Jakub
- dc.date.accessioned 2020-10-20T06:01:53Z
- dc.date.available 2020-10-20T06:01:53Z
- dc.date.issued 2020
- dc.description.abstract Foxp3+ regulatory T cells (Tregs) are potent suppressor cells, essential for the maintenance of immune homeostasis. Most Tregs develop in the thymus and are then released into the immune periphery. However, some Tregs populate the thymus and constitute a major subset of yet poorly understood cells. Here we describe a subset of thymus recirculating IL18R+ Tregs with molecular characteristics highly reminiscent of tissue-resident effector Tregs. Moreover, we show that IL18R+ Tregs are endowed with higher capacity to populate the thymus than their IL18R- or IL18R-/- counterparts, highlighting the key role of IL18R in this process. Finally, we demonstrate that IL18 signaling is critical for the induction of the key thymus-homing chemokine receptor - CCR6 on Tregs. Collectively, this study provides a detailed characterization of the mature Treg subsets in the mouse thymus and identifies a key role of IL18 signaling in controlling the CCR6-CCL20-dependent migration of Tregs into the thymus.
- dc.description.sponsorship Research in the Abramson laboratory is kindly supported by the European Research Council (ERC-2016-CoG-724821), Israel Science Foundation (1796/16), Sy Syms Foundation, Bill and Marika Glied and Family Fund, Wohl Biology Endowment Fund, Erica Drake Fund, The Enoch Foundation, Ruth and Samuel David Gameroff Family Foundation, and Lilly Fulop Fund for Multiple Sclerosis Research. CP was supported by Weizmann-La Caixa fellowship and Weizmann-Dean of faculty fellowship.
- dc.format.mimetype application/pdf
- dc.identifier.citation Peligero-Cruz C, Givony T, Sebé-Pedrós A, Dobeš J, Kadouri N, Nevo S, Roncato F, Alon R, Goldfarb Y, Abramson J. IL18 signaling promotes homing of mature Tregs into the thymus. Elife. 2020; 9:e58213. DOI: 10.7554/eLife.58213
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.58213
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/45516
- dc.language.iso eng
- dc.publisher eLife
- dc.relation.ispartof Elife. 2020; 9:e58213
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724821
- dc.rights © 2020, Peligero-Cruz et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword CCR6
- dc.subject.keyword IL18R
- dc.subject.keyword Tregs
- dc.subject.keyword Immunology
- dc.subject.keyword Inflammation
- dc.subject.keyword Migration
- dc.subject.keyword Mouse
- dc.subject.keyword Recirculation
- dc.subject.keyword Thymus
- dc.title IL18 signaling promotes homing of mature Tregs into the thymus
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion