Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year

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  • dc.contributor.author Selma Royo, Marta
  • dc.contributor.author Dubois, Léonard
  • dc.contributor.author Manara, Serena
  • dc.contributor.author Armanini, Federica
  • dc.contributor.author Cabrera Rubio, Raúl
  • dc.contributor.author Vallès Colomer, Mireia
  • dc.contributor.author González, Sonia
  • dc.contributor.author Parra Llorca, Anna
  • dc.contributor.author Escuriet Peiró, Ramón, 1968-
  • dc.contributor.author Bode, Lars
  • dc.contributor.author Martínez Costa, Cecilia
  • dc.contributor.author Segata, Nicola
  • dc.contributor.author Collado, María Carmen
  • dc.date.accessioned 2024-07-15T06:47:00Z
  • dc.date.available 2024-07-15T06:47:00Z
  • dc.date.issued 2024
  • dc.description.abstract The composition and maturation of the early-life microbiota are modulated by a number of perinatal factors, whose interplay in relation to microbial vertical transmission remains inadequately elucidated. Using recent strain-tracking methodologies, we analyzed mother-to-infant microbiota transmission in two different birth environments: hospital-born (vaginal/cesarean) and home-born (vaginal) infants and their mothers. While delivery mode primarily explains initial compositional differences, place of birth impacts transmission timing-being early in homebirths and delayed in cesarean deliveries. Transmission patterns vary greatly across species and birth groups, yet certain species, like Bifidobacterium longum, are consistently vertically transmitted regardless of delivery setting. Strain-level analysis of B. longum highlights relevant and consistent subspecies replacement patterns mainly explained by breastfeeding practices, which drive changes in human milk oligosaccharide (HMO) degrading capabilities. Our findings highlight how delivery setting, breastfeeding duration, and other lifestyle preferences collectively shape vertical transmission, impacting infant gut colonization during early life.
  • dc.description.sponsorship We would like to thank the Biobank (Biobanco para la Investigación Biomédica y en Salud Pública de la Comunidad Valenciana, IBSP-CV) for their work in processing the biological samples. The MAMI team would like to acknowledge the support from H2020-ERC Starting Grant (MAMI-639226 project) and from Spanish Ministry of Science and Innovation (MCIN) research grant (ref. PID2022-139475OB-I00). R.C.-R. thanks Generalitat Valenciana for the grant Plan GenT project (CDEIGENT 2020). M.C.C., M.-S.R., and R.C.-R. would also like to acknowledge the award of the Spanish Government MCIN/AEI to the Institute of Agrochemistry and Food Technology (IATA-CSIC) as Centre of Excellence Severo Ochoa (CEX2021-001189-S MCIN/AEI/10.13039/ 501100011033). This work was also supported by the European Research Council (ERC-STG project MetaPG-716575 and ERC-CoG microTOUCH-101045015) to N.S., by the European H2020 programme (ONCOBIOME-825410 project, MASTER-818368 project, and IHMCSA-964590) to N.S., by the National Cancer Institute of the National Institutes of Health (1U01CA230551) to N.S., and by EMBO ALTF 593–2020 to M.V.-C.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Selma-Royo M, Dubois L, Manara S, Armanini F, Cabrera-Rubio R, Valles-Colomer M, et al. Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year. Cell Host Microbe. 2024 Jun 12;32(6):996-1010.e4. DOI: 10.1016/j.chom.2024.05.005
  • dc.identifier.doi http://dx.doi.org/10.1016/j.chom.2024.05.005
  • dc.identifier.issn 1931-3128
  • dc.identifier.uri http://hdl.handle.net/10230/60745
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Cell Host Microbe. 2024 Jun 12;32(6):996-1010.e4
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/639226
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-139475OB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/CEX2021-001189-S
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/716575
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101045015
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825410
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/818368
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/964590
  • dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Breast milk
  • dc.subject.keyword Early life
  • dc.subject.keyword Infant
  • dc.subject.keyword Maternal transmission
  • dc.subject.keyword Microbiota
  • dc.subject.keyword Strain sharing
  • dc.subject.keyword Vertical transmission
  • dc.title Birthmode and environment-dependent microbiota transmission dynamics are complemented by breastfeeding during the first year
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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