A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons
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- dc.contributor.author Cofán, Montserrat
- dc.contributor.author Checa, Antonio
- dc.contributor.author Serra-Mir, Mercè
- dc.contributor.author Roth, Irene
- dc.contributor.author Valls Pedret, Cinta
- dc.contributor.author López Illamola, Anna
- dc.contributor.author Doménech, Mónica
- dc.contributor.author Rajaram, Sujatha
- dc.contributor.author Lázaro, Iolanda
- dc.contributor.author Sabaté, Joan
- dc.contributor.author Ros, Emilio
- dc.contributor.author Wheelock, Craig E.
- dc.contributor.author Sala Vila, Aleix
- dc.date.accessioned 2024-10-28T07:21:08Z
- dc.date.embargoEnd info:eu-repo/date/embargoEnd/2024-12-09
- dc.date.issued 2024
- dc.description.abstract Background: Oxylipins are products derived from polyunsaturated fatty acids (PUFAs) that play a role in cardiovascular disease and aging. Fish oil-derived n-3 PUFAs promote the formation of anti-inflammatory and vasodilatory oxylipins; however, there are little data on oxylipins derived from α-linolenic acid (C18:3n-3), the primary plant-derived n-3 PUFA. Walnuts are a source of C18:3n-3. Objectives: To investigate the effect on serum oxylipins of a diet enriched with walnuts at 15% energy (30-60 g/d; 2.6-5.2 g C18:3n-3/d) for 2 y compared to a control diet (abstention from walnuts) in healthy older males and females (63-79 y). Methods: The red blood cell proportion of α-linolenic acid was determined by gas chromatography as a measure of compliance. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure serum concentrations of 53 oxylipins in participants randomly assigned to receive the walnut diet (n = 64) or the control diet (n = 51). Two-year concentration changes (final minus baseline) were log-transformed (base log-10) and standardized (mean-centered and divided by the standard deviation of each variable). Volcano plots were then generated (fold change ≥1.5; false discovery rate ≤0.1). For each oxylipin delta surviving multiple testing, we further assessed between-intervention group differences by analysis of covariance adjusting for age, sex, BMI, and the baseline concentration of the oxylipin. Results: The 2-y change in red blood cell C18:3n-3 in the walnut group was significantly higher than that in the control group (P < 0.001). Compared to the control diet, the walnut diet resulted in statistically significantly greater increases in 3 C18:3n-3-derived oxylipins (9-HOTrE, 13-HOTrE, and 12,13-EpODE) and in the C20:5n-3 derived 14,15-diHETE, and greater reductions of the C20:4n-6-derived 5-HETE, 19-HETE, and 5,6-diHETrE. Conclusions: Long-term walnut consumption changes the serum oxylipin profile in healthy older persons. Our results add novel mechanistic evidence on the cardioprotective effects of walnuts. Trial registration: Clinicaltrials.gov Identifier: NCT01634841.
- dc.embargo.liftdate 2024-12-09
- dc.format.mimetype application/pdf
- dc.identifier.citation Cofán M, Checa A, Serra-Mir M, Roth I, Valls-Pedret C, Lopez-Illamola A, et al. A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons. J Nutr. 2024 Feb;154(2):395-402. DOI: 10.1016/j.tjnut.2023.12.007
- dc.identifier.doi http://dx.doi.org/10.1016/j.tjnut.2023.12.007
- dc.identifier.issn 0022-3166
- dc.identifier.uri http://hdl.handle.net/10230/68358
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof J Nutr. 2024 Feb;154(2):395-402
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.tjnut.2023.12.007
- dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
- dc.subject.keyword Arachidonic acid
- dc.subject.keyword Biomarker
- dc.subject.keyword Diet
- dc.subject.keyword Inflammation
- dc.subject.keyword Lipidomics
- dc.subject.keyword n-3
- dc.subject.keyword Nuts
- dc.subject.keyword Omega-3
- dc.subject.keyword Plant-based foods
- dc.subject.keyword α-linolenic acid
- dc.title A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion