Differences in breast cancer risk after benign breast disease by type of screening diagnosis
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- dc.contributor.author Louro, Javier
- dc.contributor.author Román, Marta
- dc.contributor.author Posso, Margarita
- dc.contributor.author Comerma Blesa, Laura, 1983-
- dc.contributor.author Vidal, Carmen
- dc.contributor.author Saladié, Francina
- dc.contributor.author Alcántara da Silva, Rodrigo
- dc.contributor.author Sánchez, Mar
- dc.contributor.author Quintana, María Jesús
- dc.contributor.author Del Riego, Javier
- dc.contributor.author Ferrer, Joana
- dc.contributor.author Peñalva, Lupe
- dc.contributor.author Bargalló Castelló, Xavier
- dc.contributor.author Prieto, Miguel
- dc.contributor.author Sala Serra, Maria
- dc.contributor.author Castells, Xavier
- dc.date.accessioned 2021-06-03T07:09:18Z
- dc.date.available 2021-06-03T07:09:18Z
- dc.date.issued 2020
- dc.description.abstract Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis.
- dc.format.mimetype application/pdf
- dc.identifier.citation Louro J, Román M, Posso M, Comerma L, Vidal C, Saladié F, et al. Differences in breast cancer risk after benign breast disease by type of screening diagnosis. Breast. 2020 Dec; 54 :343-8. DOI: 10.1016/j.breast.2020.09.005
- dc.identifier.doi http://dx.doi.org/10.1016/j.breast.2020.09.005
- dc.identifier.issn 0960-9776
- dc.identifier.uri http://hdl.handle.net/10230/47746
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights Copyright © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Benign breast disease
- dc.subject.keyword Breast neoplasms
- dc.subject.keyword Early cancer detection
- dc.subject.keyword Risk factors
- dc.title Differences in breast cancer risk after benign breast disease by type of screening diagnosis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion