Genetic characterization of the ABO blood group in Neandertals

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• dc.contributor.author Lalueza Fox, Carles, 1965-ca
• dc.contributor.author Gigli, Elena, 1978-ca
• dc.contributor.author Rasilla Vives, Marco de laca
• dc.contributor.author Fortea, Javierca
• dc.contributor.author Rosas, Antonioca
• dc.contributor.author Bertranpetit, Jaume, 1952-ca
• dc.contributor.author Krause, Johannesca
• dc.date.accessioned 2012-05-03T08:26:02Z
• dc.date.available 2012-05-03T08:26:02Z
• dc.date.issued 2008ca
• dc.description.abstract Background: The high polymorphism rate in the human ABO blood group gene seems to be related to susceptibility to different pathogens. It has been estimated that all genetic variation underlying the human ABO alleles appeared along the human lineage, after the divergence from the chimpanzee lineage. A paleogenetic analysis of the ABO blood group gene in Neandertals allows us to directly test for the presence of the ABO alleles in these extinct humans. Results: We have analysed two male Neandertals that were retrieved under controlled conditions at the El Sidron site in Asturias (Spain) and that appeared to be almost free of modern human DNA contamination. We find a human specific diagnostic deletion for blood group O (O01 haplotype) in both Neandertal individuals. Conclusion: These results suggest that the genetic change responsible for the O blood group in humans predates the human and Neandertal divergence. A potential selective event associated with the emergence of the O allele may have therefore occurred after humans separated from their common ancestor with chimpanzees and before the human-Neandertal population divergence.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Lalueza-Fox C, Gigli E, Rasilla M, Fortea J, Rosas A, Bertranpetit J, Krause J. Genetic characterization of the ABO blood group in Neandertals. BMC Evol. Biol. 2008;8:342. DOI: 10.1186/1471-2148-8-342ca
• dc.identifier.doi http://dx.doi.org/10.1186/1471-2148-8-342
• dc.identifier.issn 1471-2148ca
• dc.identifier.uri http://hdl.handle.net/10230/16389
• dc.language.iso engca
• dc.publisher BioMed Centralca
• dc.relation.ispartof BMC Evolutionary Biology. 2008;8:342
• dc.rights © 2008 Lalueza-Fox et al. Creative Commons Attribution Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/2.0/
• dc.subject.other Neandertals -- Genètica
• dc.subject.other Genètica evolutiva
• dc.subject.other ADN mitocondrial -- Genètica
• dc.title Genetic characterization of the ABO blood group in Neandertalsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersion