Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

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• dc.contributor.author Asnicar, Francesco
• dc.contributor.author Vallès Colomer, Mireia
• dc.contributor.author Segata, Nicola
• dc.date.accessioned 2024-07-11T14:26:37Z
• dc.date.available 2024-07-11T14:26:37Z
• dc.date.issued 2021
• dc.description.abstract The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.
• dc.description.sponsorship This work was supported by Zoe Global and received support from grants from the Wellcome Trust (no. 212904/Z/18/Z) and Medical Research Council/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (no. MR/M016560/1). The work was also supported by the European Research Council (ERC-STG project MetaPG-716575 to N.S.), MIUR ‘Futuro in Ricerca’ (grant no. RBFR13EWWI_001 to N.S.), the European H2020 program (ONCOBIOME-825410 and MASTER-818368 projects to N.S.), the National Cancer Institute of the National Institutes of Health (grant no. 1U01CA230551 to N.S.) and the Premio Internazionale Lombardia e Ricerca 2019 to N.S. S.E.B. was supported in part by a grant funded by the Biotechnology and Biological Sciences Research Council (grant no. BB/NO12739/1). P.W.F. was supported in part by grants from the European Research Council (grant no. CoG-2015_681742_NASCENT), Swedish Research Council (grant no. IRC15-0067) and Novo Nordisk Foundation. A.T.C. was supported in part as a Stuart and Suzanne Steele MGH Research Scholar. TwinsUK is funded by the Wellcome Trust, Medical Research Council, European Union, Chronic Disease Research Foundation, Zoe Global and the National Institute for Health Research-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London.
• dc.format.mimetype application/pdf
• dc.identifier.citation Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021 Feb;27(2):321-32. DOI: 10.1038/s41591-020-01183-8
• dc.identifier.doi http://dx.doi.org/10.1038/s41591-020-01183-8
• dc.identifier.issn 1078-8956
• dc.identifier.uri http://hdl.handle.net/10230/60733
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Med. 2021 Feb;27(2):321-32
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/716575
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825410
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/818368
• dc.rights © Springer Nature Publishing AG Asnicar F, Berry SE, Valdes AM, Nguyen LH, Piccinno G, Drew DA, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021 Feb;27(2):321-32. DOI: 10.1038/s41591-020-01183-8 [http://dx.doi.org/10.1038/s41591-020-01183-8]
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Metabolism
• dc.subject.keyword Metagenomics
• dc.subject.keyword Microbiome
• dc.title Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion