Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli

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• dc.contributor.author Berbegal-Sáez, Paula
• dc.contributor.author Gallego-Landin, Ines
• dc.contributor.author Macía, Javier
• dc.contributor.author Alegre Zurano, Laia
• dc.contributor.author Castro Zavala, Adriana, 1988-
• dc.contributor.author Welz, Patrick-Simon
• dc.contributor.author Benitah, Salvador A.
• dc.contributor.author Valverde Granados, Olga
• dc.date.accessioned 2024-09-18T06:26:06Z
• dc.date.available 2024-09-18T06:26:06Z
• dc.date.issued 2024
• dc.description.abstract Maintaining proper circadian rhythms is essential for coordinating biological functions in mammals. This study investigates the effects of daily arrhythmicity using Bmal1-knockout (KO) mice as a model, aiming to understand behavioural and motivational implications. By employing a new mathematical analysis based on entropy divergence, we identified disrupted intricate activity patterns in mice derived by the complete absence of BMAL1 and quantified the difference regarding the activity oscillation's complexity. Changes in locomotor activity coincided with disturbances in circadian gene expression patterns. Additionally, we found a dysregulated gene expression profile particularly in brain nuclei like the ventral striatum, impacting genes related to reward and motivation. Further investigation revealed that arrhythmic mice exhibited heightened motivation for food and water rewards, indicating a link between circadian disruptions and the reward system. This research sheds light on how circadian clock alterations impact the gene expression regulating the reward system and how this, in turn, can lead to altered seeking behaviour and motivation for natural rewards. In summary, the present study contributes to our understanding of how reward processing is under the regulation of circadian clock machinery.
• dc.description.sponsorship This work was supported by a grant from the Ministerio de Ciencia, Innovación y Universidades (PID2022-136962OB-100-MICIU/AEI/10.13039/501100011033 and ERDF/EU), by Ministerio de Sanidad, Delegación del Gobierno para el Plan Nacional sobre Drogas (2023/005) and Fondos de Recuperación, Transformación y Resiliencia (PRTR) Unión Europea (Exp2022/008695) and by the Generalitat de Catalunya, AGAUR (2021SGR00485). P.B-S is supported by FI-AGAUR grant from the Generalitat de Catalunya (2021FI-B00205). I.G-L. is supported by a grant from the Ministerio de Ciencia e Innovación (PRE2020-091923). The Department of Medicine and Health Sciences (UPF) is a 'Unidad de Excelencia María de Maeztu' funded by the AEI (CEX2018-000792-M). O.V. is recipient of an ICREA Academia Award (Institució Catalana de Recerca i Estudis Avançats, Generalitat de Catalunya). J.M. is supported by Ministerio de Ciencia, Innovación y Universidades (PID2020-119538RB-I00-MICIU /AEI/10.13039/501100011033 and ERDF/EU). P.-S.W. is supported by grant RYC2019-026661-I funded by MCIN/AEI/10.13039/501100011033 and by 'ESF Investing in your future'.
• dc.format.mimetype application/pdf
• dc.identifier.citation Berbegal-Sáez P, Gallego-Landin I, Macía J, Alegre-Zurano L, Castro-Zavala A, Welz PS, et al. Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli. Open Biol. 2024 Jul;14(7):240051. DOI: 10.1098/rsob.240051
• dc.identifier.doi http://dx.doi.org/10.1098/rsob.240051
• dc.identifier.issn 2046-2441
• dc.identifier.uri http://hdl.handle.net/10230/61134
• dc.language.iso eng
• dc.publisher Royal Society
• dc.relation.ispartof Open Biol. 2024 Jul;14(7):240051
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136962OB-100
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PRE2020-091923
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000792-M
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-119538RB-I00
• dc.rights © 2024 The Author(s). Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Bmal1
• dc.subject.keyword Circadian disruption
• dc.subject.keyword Daily rhythms
• dc.subject.keyword Natural reinforcer
• dc.subject.keyword Reward system
• dc.title Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion