Role of PRC2-associated factors in stem cells and disease

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  • dc.contributor.author Vizán, Pedroca
  • dc.contributor.author Beringer, Malteca
  • dc.contributor.author Ballaré, Cecilia Juliaca
  • dc.contributor.author Di Croce, Lucianoca
  • dc.date.accessioned 2016-07-22T13:16:46Z
  • dc.date.available 2016-07-22T13:16:46Z
  • dc.date.issued 2015
  • dc.description.abstract The Polycomb group (PcG) of proteins form chromatin-binding complexes with histone-modifying activity. The two main PcG repressive complexes studied (PRC1 and PRC2) are generally associated with chromatin in its repressed state. PRC2 is responsible for methylation of histone H3 at lysine 27 (H3K27me3), an epigenetic mark that is linked with numerous biological processes, including development, adult homeostasis and cancer. The core canonical complex PRC2, which contains the EZH1/2, SUZ12 and EED proteins, may be extended and functionally manipulated through interactions with several other proteins. In this review, we focus on these PRC2-associated proteins. As PRC2 functions are diverse, the variability conferred by these sub-stoichiometrically associated members may help to understand specific changes in PRC2 activity, chromatin recruitment and distribution required for gene repression.ca
  • dc.description.sponsorship This work was supported by grants from the Spanish “Ministerio de Educación y Ciencia” (SAF2013-48926-P), from AGAUR, “Fundació a Marató” (20131110), and from the European Commission's 7th Framework Program 4DCellFate grant number 277899 to L.D.C.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Vizán P, Beringer M, Ballaré C, Di Croce L. Role of PRC2-associated factors in stem cells and disease. FEBS Journal. 2015;282(9):1723-35. DOI: 10.1111/febs.13083ca
  • dc.identifier.doi http://dx.doi.org/10.1111/febs.13083
  • dc.identifier.issn 1742-464X
  • dc.identifier.uri http://hdl.handle.net/10230/27108
  • dc.language.iso engca
  • dc.publisher Wiley-Blackwellca
  • dc.relation.ispartof FEBS Journal. 2015;282(9):1723-35
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/277899
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-48926-P
  • dc.rights This is the pre-peer reviewed version of the following article: Vizán P, Beringer M, Ballaré C, Di Croce L. Role of PRC2-associated factors in stem cells and disease. FEBS Journal. 2015; 282(9): 1723-1735. DOI 10.1111/febs.13083, which has been published in final form at http://dx.doi.org/10.1111/febs.13083. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.keyword AEBP2
  • dc.subject.keyword C17orf96
  • dc.subject.keyword JARID2
  • dc.subject.keyword RBAP46/48
  • dc.subject.keyword Chromatin
  • dc.subject.keyword Epigenetics
  • dc.subject.keyword Gene expression
  • dc.subject.keyword Polycomb
  • dc.subject.keyword Polycomb-like
  • dc.subject.keyword Stem cells
  • dc.subject.other Cèl·lules mareca
  • dc.title Role of PRC2-associated factors in stem cells and diseaseca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/acceptedVersionca