A comprehensive analysis of the abdominal aortic aneurysm growth rate in the Spanish population

Peypoch, Olga; Calsina Juscafresa, Laura; Vega Méndez, Antón; Lobato-Delgado, Bárbara; Fité, Joan; Soto, Begoña; Nieto, Lluis; de la Rosa Estadella, Mireia; Uribezubia, Ager; Romero, Jose-María; Plana, Emma; Miralles, Manuel; Clará Velasco, Alberto; Dilmé, Jaume; Soria, José Manuel; Camacho, Mercedes; Martinez-Perez, Angel; Sabater-Lleal, Maria

A comprehensive analysis of the abdominal aortic aneurysm growth rate in the Spanish population

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dc.contributor.author Peypoch, Olga
dc.contributor.author Calsina Juscafresa, Laura
dc.contributor.author Vega Méndez, Antón
dc.contributor.author Lobato-Delgado, Bárbara
dc.contributor.author Fité, Joan
dc.contributor.author Soto, Begoña
dc.contributor.author Nieto, Lluis
dc.contributor.author de la Rosa Estadella, Mireia
dc.contributor.author Uribezubia, Ager
dc.contributor.author Romero, Jose-María
dc.contributor.author Plana, Emma
dc.contributor.author Miralles, Manuel
dc.contributor.author Clará Velasco, Alberto
dc.contributor.author Dilmé, Jaume
dc.contributor.author Soria, José Manuel
dc.contributor.author Camacho, Mercedes
dc.contributor.author Martinez-Perez, Angel
dc.contributor.author Sabater-Lleal, Maria
dc.date.accessioned 2025-09-09T06:32:07Z
dc.date.available 2025-09-09T06:32:07Z
dc.date.issued 2025
dc.description.abstract Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.en
dc.description.sponsorship TABS is funded by the Spanish Ministry of Science and Innovation (Agencia Estatal de Investigación) projects PID2019-109844RB-I00 and PID2023-149864OB-I00, and by project 202334-30-31 from Fundació La Marató de 3CAT. Maria Sabater-Lleal is supported by a Miguel Servet contract from the ISCIII Spanish Health Institute (Instituto de Salud Carlos III, CPII22/00007) and co-financed by the European Social Fund. Samples and data from patients provided by Hospital La Fe, Valencia, were managed by Biobank La Fe (PT17/0015/0043) after approval by the scientific and ethical committees. We acknowledge support from Red de Investigación en Patología Aórtica (RED2022-134541-T).en
dc.format.mimetype application/pdf
dc.identifier.citation Peypoch O, Calsina L, Vega-Méndez A, Lobato-Delgado B, Fité J, Soto B, et al. A comprehensive analysis of the abdominal aortic aneurysm growth rate in the Spanish population. J Clin Med. 2025 Jul 1;14(13):4720. DOI: 10.3390/jcm14134720
dc.identifier.doi http://dx.doi.org/10.3390/jcm14134720
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/71163
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Journal of Clinical Medicine. 2025 Jul 1;14(13):4720
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-109844RB-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2023-149864OB-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/RED2022-134541-T
dc.rights © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword Abdominal Aortic Aneurysm (AAA)en
dc.subject.keyword Risk prediction modelsen
dc.subject.keyword AAA screeningen
dc.subject.keyword Risk factorsen
dc.title A comprehensive analysis of the abdominal aortic aneurysm growth rate in the Spanish populationen
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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