Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study

Biarnés Pérez, Marc, 1973-; Arias, Luis; Alonso Caballero, Jordi; García, Míriam; Hijano, Míriam; Rodríguez, Anabel; Serrano, Anna; Badal, Josep; Muhtaseb, Hussein; Verdaguer, Paula; Monés, Jordi (Monés Carilla)

Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study

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dc.contributor.author Biarnés Pérez, Marc, 1973-ca
dc.contributor.author Arias, Luisca
dc.contributor.author Alonso Caballero, Jordica
dc.contributor.author García, Míriamca
dc.contributor.author Hijano, Míriamca
dc.contributor.author Rodríguez, Anabelca
dc.contributor.author Serrano, Annaca
dc.contributor.author Badal, Josepca
dc.contributor.author Muhtaseb, Husseinca
dc.contributor.author Verdaguer, Paulaca
dc.contributor.author Monés, Jordi (Monés Carilla)ca
dc.date.accessioned 2015-10-13T09:40:16Z
dc.date.available 2016-08-31T02:00:04Z
dc.date.issued 2015
dc.description.abstract PURPOSE: To define the role of increased fundus autofluorescence (FAF), a surrogate for lipofuscin content, as a risk factor for progression of geographic atrophy (GA). DESIGN: Prospective natural history cohort study, the GAIN (Characterization of geographic atrophy progression in patients with age-related macular degeneration). METHODS: setting: Single-center study conducted in Barcelona, Spain. PATIENTS: After screening of 211 patients, 109 eyes of 82 patients with GA secondary to age-related macular degeneration and a minimum follow-up of 6 months were included. OBSERVATION PROCEDURES: Lipofuscin content was classified independently by 2 masked observers according to FAF patterns described previously. Bivariate, stratified, and multivariable analyses were used to explore the associations between GA growth and independent variables. Mediation analysis was used to evaluate the contribution of FAF patterns to GA progression. MAIN OUTCOME: Progression of GA in mm(2)/year as measured with FAF. RESULTS: Median follow-up was 18 months (range, 6-42). Median GA growth was 1.61 mm(2)/year. FAF, baseline area of atrophy, and time of follow-up were independently associated with GA progression (P < .004). FAF patterns and baseline area of atrophy were strongly associated (P < .0001), suggesting potential confounding. Mediation analysis suggested that most of the effect of FAF patterns on GA growth was actually caused by baseline area of atrophy. CONCLUSIONS: FAF patterns, baseline area of atrophy, and time of follow-up were associated with GA progression. However, FAF patterns seem to be a consequence (not a cause) of enlarging atrophy and their effect on GA progression seems mostly driven by baseline area of atrophy.ca
dc.format.mimetype application/pdfca
dc.identifier.citation Biarnés M, Arias L, Alonso J, Garcia M, Hijano M, Rodríguez A. et al. Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN study. Am J Ophthalmol. 2015 Aug;160(2):345-53. DOI: 10.1016/j.ajo.2015.05.009.ca
dc.identifier.doi http://dx.doi.org/10.1016/j.ajo.2015.05.009
dc.identifier.issn 0002-9394
dc.identifier.uri http://hdl.handle.net/10230/24835
dc.language.iso engca
dc.publisher Elsevier Scienceca
dc.relation.ispartof American Journal of Ophthalmology. 2015 Aug;160(2):345-53
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Degeneració macularca
dc.title Increased fundus autofluorescence and progression of geographic atrophy secondary to age-related macular degeneration: the GAIN studyca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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