Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children

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• dc.contributor.author Moccia, Chiara
• dc.contributor.author Pizzi, Costanza
• dc.contributor.author Moirano, Giovenale
• dc.contributor.author Popovic, Maja
• dc.contributor.author Zugna, Daniela
• dc.contributor.author D'Errico, Antonio
• dc.contributor.author Isaevska, Elena
• dc.contributor.author Fossati, Serena
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Fariselli, Piero
• dc.contributor.author Sanavia, Tiziana
• dc.contributor.author Richiardi, Lorenzo
• dc.contributor.author Maule, Milena
• dc.date.accessioned 2025-04-29T09:45:18Z
• dc.date.available 2025-04-29T09:42:31Z
• dc.date.issued 2023
• dc.description Includes supplementary materials for the online appendix.
• dc.description.abstract Background. The exposome drivers are less studied than its consequences but may be crucial in identifying population subgroups with unfavourable exposures. Objectives. We used three approaches to study the socioeconomic position (SEP) as a driver of the early-life exposome in Turin children of the NINFEA cohort (Italy). Methods. Forty-two environmental exposures, collected at 18 months of age (N = 1989), were classified in 5 groups (lifestyle, diet, meteoclimatic, traffic-related, built environment). We performed cluster analysis to identify subjects sharing similar exposures, and intra-exposome-group Principal Component Analysis (PCA) to reduce the dimensionality. SEP at childbirth was measured through the Equivalised Household Income Indicator. SEP-exposome association was evaluated using: 1) an Exposome Wide Association Study (ExWAS), a one-exposure (SEP) one-outcome (exposome) approach; 2) multinomial regression of cluster membership on SEP; 3) regressions of each intra-exposome-group PC on SEP. Results. In the ExWAS, medium/low SEP children were more exposed to greenness, pet ownership, passive smoking, TV screen and sugar; less exposed to NO2, NOX, PM25abs, humidity, built environment, traffic load, unhealthy food facilities, fruit, vegetables, eggs, grain products, and childcare than high SEP children. Medium/low SEP children were more likely to belong to a cluster with poor diet, less air pollution, and to live in the suburbs than high SEP children. Medium/low SEP children were more exposed to lifestyle PC1 (unhealthy lifestyle) and diet PC2 (unhealthy diet), and less exposed to PC1s of the built environment (urbanization factors), diet (mixed diet), and traffic (air pollution) than high SEP children. Conclusions. The three approaches provided consistent and complementary results, suggesting that children with lower SEP are less exposed to urbanization factors and more exposed to unhealthy lifestyles and diet. The simplest method, the ExWAS, conveys most of the information and is more replicable in other populations. Clustering and PCA may facilitate results interpretation and communication.en
• dc.description.sponsorship The NINFEA study was partially funded by the Compagnia San Paolo Foundation. This research was partially funded by the Italian Ministry for Education, University and Research (Ministero dell’Istruzione, dell’Università e della Ricerca – MIUR) under the programme “Dipartimenti di Eccellenza 2018–2022“, by the European Union’s Horizon 2020 research and innovation programme ATHLETE, grant agreement number 874583. This publication reflects only the authors’ view and the European Commission is not responsible for any use that may be made of the information it contains.en
• dc.format.mimetype application/pdf
• dc.identifier.citation Moccia C, Pizzi C, Moirano G, Popovic M, Zugna D, d'Errico A, et al. Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort children. Environ Int. 2023 Mar;173:107864. DOI: 10.1016/j.envint.2023.107864
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.107864
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/70231
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environment International. 2023 Mar;173:107864
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.rights © The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Exposomeen
• dc.subject.keyword Socioeconomic positionen
• dc.subject.keyword Life course epidemiologyen
• dc.subject.keyword Health inequalitiesen
• dc.subject.keyword Environmental epidemiologyen
• dc.title Modelling socioeconomic position as a driver of the exposome in the first 18 months of life of the NINFEA birth cohort childrenen
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion