Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial

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• dc.contributor.author Kurnikowski, Amelie
• dc.contributor.author Nordheim, Espen
• dc.contributor.author Schwaiger, Elisabeth
• dc.contributor.author Krenn, Simon
• dc.contributor.author Harreiter, Jürgen
• dc.contributor.author Kautzky-Willer, Alexandra
• dc.contributor.author Leutner, Michael
• dc.contributor.author Werzowa, Johannes M.
• dc.contributor.author Tura, Andrea
• dc.contributor.author Budde, Klemens
• dc.contributor.author Eller, Kathrin
• dc.contributor.author Pascual Santos, Julio
• dc.contributor.author Krebs, Michael
• dc.contributor.author Jenssen, Trond Geir
• dc.contributor.author Hecking, Manfred
• dc.date.accessioned 2023-01-13T07:33:21Z
• dc.date.available 2023-01-13T07:33:21Z
• dc.date.issued 2022
• dc.description.abstract Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting plasma glucose (FPG) and HbA1c as alternatives to oral glucose tolerance test (OGTT)-derived 2-hour plasma glucose (2hPG) using sensitivity and specificity in 263 kidney transplant recipients (KTRs) from a clinical trial. Between visits at 6, 12, and 24 months after transplantation, 28%-31% of patients switched glycemic category (normal glucose tolerance [NGT], IGT/IFG, PTDM). Correlations of FPG and HbA1c against 2hPG were lower at 6 months (r = 0.59 [FPG against 2hPG]; r = 0.45 [HbA1c against 2hPG]) vs. 24 months (r = 0.73 [FPG against 2hPG]; r = 0.74 [HbA1c against 2hPG]). Up to 69% of 2hPG-defined PTDM cases were missed by conventional HbA1c and FPG thresholds. For prediabetes, concordance of FPG and HbA1c with 2hPG ranged from 6%-9%. In conclusion, in our well-defined randomized trial cohort, one-third of KTRs switched glycemic category over 2 years and although the correlations of FPG and HbA1c with 2hPG improved with time, their diagnostic concordance was poor for PTDM and, especially, prediabetes. Considering posttransplant metabolic instability, FPG's and HbA1c 's diagnostic performance, the OGTT remains indispensable to diagnose PTDM and prediabetes after kidney transplantation
• dc.format.mimetype application/pdf
• dc.identifier.citation Kurnikowski A, Nordheim E, Schwaiger E, Krenn S, Harreiter J, Kautzky-Willer A, et al. Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial. Am J Transplant. 2022 Dec; 22(12): 2880-91. DOI: 10.1111/ajt.17187
• dc.identifier.doi http://dx.doi.org/10.1111/ajt.17187
• dc.identifier.issn 1600-6135
• dc.identifier.uri http://hdl.handle.net/10230/55268
• dc.language.iso eng
• dc.publisher Wiley
• dc.rights This is the peer reviewed version of the following article: Kurnikowski A, Nordheim E, Schwaiger E, Krenn S, Harreiter J, Kautzky-Willer A, et al. Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial. Am J Transplant. 2022 Dec; 22(12): 2880-91, which has been published in final form at http://dx.doi.org/10.1111/ajt.17187. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.other Trasplantació d'òrgans, teixits, etc.
• dc.subject.other Ronyons--Trasplantació
• dc.subject.other Diabetis
• dc.title Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion