Genomic changes driving the acquisition of multidrug resistance in Candida glabrata
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Księżopolska, Ewa
- dc.contributor.other Gabaldón Estevan, Juan Antonio
- dc.contributor.other Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut
- dc.date.accessioned 2024-10-19T01:36:04Z
- dc.date.available 2024-10-19T01:36:04Z
- dc.date.issued 2021-09-08T16:29:09Z
- dc.date.issued 2022-07-05T00:00:15Z
- dc.date.issued 2021-07-05
- dc.date.modified 2024-10-03T03:41:05Z
- dc.description.abstract This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to find the mutational signatures of drug resistance and cross-resistance to representatives of two clinically important antifungal drug classes, azoles and echinocandins. By combining in vitro evolution with phenotypic screening and comparative genomics analysis we investigated the relationship between genomic changes, fitness and drug susceptibility to shed light on the cellular mechanisms and evolutionary constraints of antifungal drug resistance in this important pathogen
- dc.description.abstract Programa de doctorat en Biomedicina
- dc.format 232 p.
- dc.format application/pdf
- dc.format application/pdf
- dc.identifier http://hdl.handle.net/10803/672386
- dc.identifier.uri http://hdl.handle.net/10230/48431
- dc.language.iso eng
- dc.rights L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació deles condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by/4.0/
- dc.rights http://creativecommons.org/licenses/by/4.0/
- dc.rights info:eu-repo/semantics/openAccess
- dc.source TDX (Tesis Doctorals en Xarxa)
- dc.subject.keyword Candida glabrata
- dc.subject.keyword Experimental evolution
- dc.subject.keyword Antifungal
- dc.subject.keyword Drug resistance
- dc.subject.keyword Cross resistance
- dc.subject.keyword Multidrug resistance
- dc.subject.keyword Resistencia a fármacos antimicóticos
- dc.subject.keyword 615
- dc.title Genomic changes driving the acquisition of multidrug resistance in Candida glabrata
- dc.type info:eu-repo/semantics/doctoralThesis
- dc.type info:eu-repo/semantics/publishedVersion