Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression

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• dc.contributor.author Henríquez Hernández, Luis Alberto
• dc.contributor.author Valenciano, Almudena
• dc.contributor.author Foro Arnalot, Palmira
• dc.contributor.author Álvarez Cubero, María Jesús
• dc.contributor.author Cozar, José Manuel
• dc.contributor.author Suárez Novo, José Francisco
• dc.contributor.author Castells Esteve, Manel
• dc.contributor.author Fernández Gonzalo, Pablo
• dc.contributor.author De-Paula Carranza, Belén
• dc.contributor.author Ferrer Forés, Maria Montserrat
• dc.contributor.author Guedea, Ferrán
• dc.contributor.author Sancho-Pardo, Gemma
• dc.contributor.author Craven-Bartle, Jordi
• dc.contributor.author Ortiz-Gordillo, María José
• dc.contributor.author Cabrera Roldán, Patricia
• dc.contributor.author Herrera Ramos, Estefanía
• dc.contributor.author Rodríguez Gallego, Carlos
• dc.contributor.author Rodríguez Melcón, Juan Ignacio
• dc.contributor.author Lara, Pedro C.
• dc.date.accessioned 2022-07-12T06:15:50Z
• dc.date.available 2022-07-12T06:15:50Z
• dc.date.issued 2014
• dc.description.abstract Background: Besides serum levels of PSA, there is a lack of prostate cancer specific biomarkers. It is need to develop new biological markers associated with the tumor behavior which would be valuable to better individualize treatment. The aim of this study was to elucidate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and prostate cancer progression. Methods: A total of 494 prostate cancer patients from a Spanish multicenter study were genotyped for 10 SNPs in XRCC1, ERCC2, ERCC1, LIG4, ATM and TP53 genes. The SNP genotyping was made in a Biotrove OpenArray® NT Cycler. Clinical tumor stage, diagnostic PSA serum levels, and Gleason score at diagnosis were obtained for all participants. Genotypic and allelic frequencies were determined using the web-based environment SNPator. Results: SNPs rs11615 (ERCC1) and rs17503908 (ATM) appeared as risk factors for prostate cancer aggressiveness. Patients wild homozygous for these SNPs (AA and TT, respectively) were at higher risk for developing cT2b - cT4 (OR = 2.21 (confidence interval (CI) 95% 1.47 - 3.31), p < 0.001) and Gleason scores ≥ 7 (OR = 2.22 (CI 95% 1.38 - 3.57), p < 0.001), respectively. Moreover, those patients wild homozygous for both SNPs had the greatest risk of presenting D'Amico high-risk tumors (OR = 2.57 (CI 95% 1.28 - 5.16)). Conclusions: Genetic variants at DNA repair genes are associated with prostate cancer progression, and would be taken into account when assessing the malignancy of prostate cancer.
• dc.format.mimetype application/pdf
• dc.identifier.citation Henríquez-Hernández LA, Valenciano A, Foro-Arnalot P, Álvarez-Cubero MJ, Cozar JM, Suárez-Novo JF, Castells-Esteve M, Fernández-Gonzalo P, De-Paula-Carranza B, Ferrer M, Guedea F, Sancho-Pardo G, Craven-Bartle J, Ortiz-Gordillo MJ, Cabrera-Roldán P, Herrera-Ramos E, Rodríguez-Gallego C, Rodríguez-Melcón JI, Lara PC. Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression. BMC Med Genet. 2014 Dec 24;15:143. DOI: 10.1186/s12881-014-0143-0
• dc.identifier.doi http://dx.doi.org/10.1186/s12881-014-0143-0
• dc.identifier.issn 1471-2350
• dc.identifier.uri http://hdl.handle.net/10230/53711
• dc.language.iso eng
• dc.publisher BioMed Central
• dc.relation.ispartof BMC Med Genet. 2014 Dec 24;15:143
• dc.rights © 2014 Henríquez-Hernández et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0
• dc.subject.keyword Single nucleotide polymorphism
• dc.subject.keyword ERCC1
• dc.subject.keyword ATM
• dc.subject.keyword Prostate cancer
• dc.subject.keyword OpenArray
• dc.subject.keyword DNA repair
• dc.subject.keyword Spanish cohort
• dc.title Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion