Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences
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- dc.contributor.author Wang, Xuejie
- dc.contributor.author Balañá Corberó, Ana, 1981-
- dc.contributor.author Martínez-Llorens, Juana Mª
- dc.contributor.author Qin, Liyun
- dc.contributor.author Xia, Yingchen
- dc.contributor.author Zha, Jianhua
- dc.contributor.author Maiques Llácer, José María
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2022-07-28T14:59:11Z
- dc.date.available 2022-07-28T14:59:11Z
- dc.date.issued 2022
- dc.description.abstract As demonstrated in COPD, bronchiectasis patients may experience respiratory and peripheral muscle dysfunction. We hypothesized that respiratory and peripheral (upper and lower limbs) muscle function and nutritional status may be more significantly altered in female than in males for identical age and disease severity. In mild-to-moderate bronchiectasis patients (n = 150, 114 females) and 37 controls (n = 37, 21 females), radiological extension, maximal inspiratory and expiratory pressures (MIP and MEP), sniff nasal inspiratory pressure (SNIP), hand grip and quadriceps muscle strengths, body composition, and blood analytical biomarkers were explored. Compared to the controls, in all bronchiectasis patients (males and females), BMI, fat-free mass index (FFMI), fat tissue, upper and lower limb muscle strength, and respiratory muscle strength significantly declined, and FFMI, fat tissue, and quadriceps muscle function were significantly lower in female than male patients. In patients with mild-to-moderate bronchiectasis, respiratory and peripheral muscle function is significantly impaired and only partly related to lung disease status. Quadriceps muscle strength was particularly weakened in the female patients and was negatively associated with their exercise tolerance. Muscle weakness should be therapeutically targeted in bronchiectasis patients. Body composition and peripheral muscle function determination should be part of the comprehensive clinical assessment of these patients.
- dc.format.mimetype application/pdf
- dc.identifier.citation Wang X, Balaña-Corberó A, Martínez-Llorens J, Qin L, Xia Y, Zha J, Maiques JM, Barreiro E. Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences. Biomedicines. 2022 Jan 31;10(2):334. DOI: 10.3390/biomedicines10020334
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines10020334
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/53877
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Biomedicines. 2022 Jan 31;10(2):334
- dc.rights © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri https://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Bronchiectasis patients
- dc.subject.keyword Differences between male and female patients
- dc.subject.keyword Lower limb muscle function
- dc.subject.keyword Muscle weakness
- dc.subject.keyword Radiological extension
- dc.subject.keyword Respiratory muscle function
- dc.subject.keyword Upper limb muscle function
- dc.title Respiratory and peripheral muscle weakness and body composition abnormalities in non-cystic fibrosis bronchiectasis patients: Gender differences
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion