Linoleic acid status in cell membranes inversely relates to the prevalence of symptomatic carotid artery disease

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• dc.contributor.author Lázaro, Iolanda
• dc.contributor.author Cofán, Montserrat
• dc.contributor.author Amor, Antonio J.
• dc.contributor.author Ortega, Emilio
• dc.contributor.author Freitas-Simoes, Tania-Marisa
• dc.contributor.author Llull, Laura
• dc.contributor.author Amaro, Sergio
• dc.contributor.author Mestres, Gaspar
• dc.contributor.author Yugueros, Xavier
• dc.contributor.author Harris, William S.
• dc.contributor.author Riambau-Alonso, Vicente
• dc.contributor.author Sala Vila, Aleix
• dc.date.accessioned 2022-02-17T07:52:30Z
• dc.date.available 2022-02-17T07:52:30Z
• dc.date.issued 2021
• dc.description.abstract Background and purpose: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease. Methods: We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography. Results: In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022-0.607], P=0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids. Conclusions: Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.
• dc.format.mimetype application/pdf
• dc.identifier.citation Lázaro I, Cofán M, Amor AJ, Ortega E, Freitas-Simoes TM, Llull L, et al. Linoleic acid status in cell membranes inversely relates to the prevalence of symptomatic carotid artery disease. Stroke. 2021 Jan; 52(2): 703-6. DOI: 10.1161/STROKEAHA.120.030477
• dc.identifier.doi http://dx.doi.org/10.1161/STROKEAHA.120.030477
• dc.identifier.issn 0039-2499
• dc.identifier.uri http://hdl.handle.net/10230/52514
• dc.language.iso eng
• dc.publisher American Hearth Association
• dc.rights © American Hearth Association http://dx.doi.org/10.1161/STROKEAHA.120.030477
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Alpha-linolenic acid
• dc.subject.keyword Carotid endarterectomy
• dc.subject.keyword Dietary fats
• dc.subject.keyword Docosahexaenoic acid
• dc.subject.keyword Phospholipids
• dc.title Linoleic acid status in cell membranes inversely relates to the prevalence of symptomatic carotid artery disease
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion