Meis2 is required for inner ear formation and proper morphogenesis of the cochlea

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• dc.contributor.author Durán Alonso, Beatriz
• dc.contributor.author Vendrell, Víctor
• dc.contributor.author López Hernández, Iris
• dc.contributor.author Alonso Pérez, María Teresa
• dc.contributor.author Martin, Donna M.
• dc.contributor.author Giráldez, Fernando
• dc.contributor.author Carramolino, Laura
• dc.contributor.author Giovinazzo, Giovanna
• dc.contributor.author Vázquez, Enrique
• dc.contributor.author Torres, Miguel S.
• dc.contributor.author Schimmang, Thomas
• dc.date.accessioned 2021-07-21T07:25:08Z
• dc.date.available 2021-07-21T07:25:08Z
• dc.date.issued 2021
• dc.description.abstract Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea. Meis2 is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of Meis2 in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of Meis2 reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from Meis2 mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for Meis2 which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that Meis2 is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct.
• dc.description.sponsorship We acknowledge grants from Mineco BFU2016-76580-P and Consejería de Educación, Junta de Castilla y León (FEDER CSI143P20) (TS).
• dc.format.mimetype application/pdf
• dc.identifier.citation Durán Alonso MB, Vendrell V, López-Hernández I, Alonso MT, Martin DM, Giráldez F, Carramolino L, Giovinazzo G, Vázquez E, Torres M, Schimmang T. Meis2 is required for inner ear formation and proper morphogenesis of the cochlea. Front Cell Dev Biol. 2021;9:679325. DOI: 10.3389/fcell.2021.679325
• dc.identifier.doi http://dx.doi.org/10.3389/fcell.2021.679325
• dc.identifier.issn 2296-634X
• dc.identifier.uri http://hdl.handle.net/10230/48259
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Cell Dev Biol. 2021;9:679325
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2016-76580-P
• dc.rights © 2021 Durán Alonso, Vendrell, López-Hernández, Alonso, Martin, Giráldez, Carramolino, Giovinazzo, Vázquez, Torres and Schimmang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Meis
• dc.subject.keyword Cochlea
• dc.subject.keyword Inner ear
• dc.subject.keyword Mouse
• dc.subject.keyword Organ of corti
• dc.title Meis2 is required for inner ear formation and proper morphogenesis of the cochlea
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion