The Pancreatic Islet Regulome Browser

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• dc.contributor.author Mularoni, Lorisca
• dc.contributor.author Ramos-Rodríguez, Mireiaca
• dc.contributor.author Pasquali, Lorenzoca
• dc.date.accessioned 2018-01-11T08:20:57Z
• dc.date.available 2018-01-11T08:20:57Z
• dc.date.issued 2017
• dc.description.abstract The pancreatic islet is a highly specialized tissue embedded in the exocrine pancreas whose primary function is that of controlling glucose homeostasis. Thus, understanding the transcriptional control of islet-cell may help to puzzle out the pathogenesis of glucose metabolism disorders. Integrative computational analyses of transcriptomic and epigenomic data allows predicting genomic coordinates of putative regulatory elements across the genome and, decipher tissue-specific functions of the non-coding genome. We herein present the Islet Regulome Browser, a tool that allows fast access and exploration of pancreatic islet epigenomic and transcriptomic data produced by different labs worldwide. The Islet Regulome Browser is now accessible on the internet or may be installed locally. It allows uploading custom tracks as well as providing interactive access to a wealth of information including Genome-Wide Association Studies (GWAS) variants, different classes of regulatory elements, together with enhancer clusters, stretch-enhancers and transcription factor binding sites in pancreatic progenitors and adult human pancreatic islets. Integration and visualization of such data may allow a deeper understanding of the regulatory networks driving tissue-specific transcription and guide the identification of regulatory variants. We believe that such tool will facilitate the access to pancreatic islet public genomic datasets providing a major boost to functional genomics studies in glucose metabolism related traits including diabetes.
• dc.description.sponsorship This work was supported by a grant from the Spanish Ministry of Economy and Competiveness (BFU2014-58150-R). LP is a recipient of a Ramon y Cajal contract from the Spanish Ministry of Economy and Competitiveness (RYC-2013-12864).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Mularoni L, Ramos-Rodríguez M, Pasquali L. The Pancreatic Islet Regulome Browser. Front Genet. 2017 Feb 14;8:13. DOI: 10.3389/fgene.2017.00013
• dc.identifier.doi http://dx.doi.org/10.3389/fgene.2017.00013
• dc.identifier.issn 1664-8021
• dc.identifier.uri http://hdl.handle.net/10230/33613
• dc.language.iso eng
• dc.publisher Frontiersca
• dc.relation.ispartof Frontiers in Genetics. 2017 Feb 14;8:13
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-58150-R
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC2013-12864
• dc.rights Copyright © 2017 Mularoni, Ramos-Rodríguez and Pasquali. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Epigenome
• dc.subject.keyword Gene regulation
• dc.subject.keyword Non-coding DNA
• dc.subject.keyword Pancreatic islet;
• dc.subject.keyword β-cells
• dc.subject.other Regulació genètica
• dc.subject.other Pàncrees
• dc.title The Pancreatic Islet Regulome Browserca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion