An ethical framework for human embryology with embryo models
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Rivron, Nicolas C.
- dc.contributor.author Martínez Arias, Alfonso
- dc.contributor.author Pera, Martin F.
- dc.contributor.author Moris, Naomi
- dc.contributor.author M'hamdi, Hafez Ismaili
- dc.date.accessioned 2023-10-02T06:47:14Z
- dc.date.available 2023-10-02T06:47:14Z
- dc.date.issued 2023
- dc.description.abstract A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest "tipping points" for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.
- dc.description.sponsorship We thank Laurent David, Sarah Franklin, Misao Fujita, Ohad Gafni, Jacob Hanna, Rudolf Jaenisch, Nick Hopwood, Kathy Niakan, Vincent Pasque, Peter Rugg-Gunn, the members of the life sciences committee of the German National Academy of Sciences Leopoldina, the members of the ethics task force of the Agence française de biomédecine, and the Dutch Beleidsmedewerkers, ministerie van volksgezondheid, welzijn en sport for the valuable discussions. Because our opinions might be different from theirs, our acknowledgment should not be considered as their endorsement. N.C.R. thanks the OEAW Austrian Academy of Sciences for receiving IMBA core funding and the European Research Council (ERC) for receiving funding under the European Union’s Horizon 2020 research and innovation program ERC-Co grant agreement No. 101002317, “BLASTOID: a discovery platform for early human embryogenesis.” A.M.A. thanks the European Research Council (grant agreement 834580) and Ministerio de Educacion y Ciencia del Gobierno de España. N.M. thanks the Francis Crick Institute for receiving its core funding from Cancer Research UK (CC2186), the UK Medical Research Council (CC2186), and the Wellcome Trust (CC2186), as well as from an MRC-AMED grant (MR/V005367/2).
- dc.format.mimetype application/pdf
- dc.identifier.citation Rivron NC, Martinez Arias A, Pera MF, Moris N, M'hamdi HI. An ethical framework for human embryology with embryo models. Cell. 2023 Aug 17;186(17):3548-57. DOI: 10.1016/j.cell.2023.07.028
- dc.identifier.doi http://dx.doi.org/10.1016/j.cell.2023.07.028
- dc.identifier.issn 0092-8674
- dc.identifier.uri http://hdl.handle.net/10230/58014
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Cell. 2023 Aug 17;186(17):3548-57
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101002317
- dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/834580
- dc.rights © 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Blastoids
- dc.subject.keyword Definition
- dc.subject.keyword Embryo
- dc.subject.keyword Embryo models
- dc.subject.keyword Embryology
- dc.subject.keyword Ethics
- dc.subject.keyword Gastruloids
- dc.subject.keyword Human
- dc.subject.keyword Legal
- dc.title An ethical framework for human embryology with embryo models
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion