Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer.

Climent Agustín, Marta Carmen; Hidalgo, Nils; Vidal, Óscar; Puig, Sonia; Iglesias García, Mar; Cuatrecasas, Miriam; Ramón Moros, José Manuel; Garcia-Albéniz, Xabier; Grande Posa, Luís; Pera Roman, Manuel Ramón

Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer.

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dc.contributor.author Climent Agustín, Marta Carmenca
dc.contributor.author Hidalgo, Nilsca
dc.contributor.author Vidal, Óscarca
dc.contributor.author Puig, Soniaca
dc.contributor.author Iglesias García, Marca
dc.contributor.author Cuatrecasas, Miriamca
dc.contributor.author Ramón Moros, José Manuelca
dc.contributor.author Garcia-Albéniz, Xabierca
dc.contributor.author Grande Posa, Luísca
dc.contributor.author Pera Roman, Manuel Ramónca
dc.date.accessioned 2016-02-24T10:49:55Z
dc.date.available 2017-01-31T03:00:05Z
dc.date.issued 2016
dc.description.abstract BACKGROUND: We assessed the impact of complications on recurrence and survival after curative gastric cancer resection. METHODS: Patients undergoing R0 resections between 1990 and 2009 were identified in a prospectively maintained database and were categorized by presence of any complication Clavien-Dindo (CD) ≥ II, sepsis or intra-abdominal sepsis. Cox regression analyses to relate complications and clinico-pathological variables to time to recurrence (TTR) and overall survival (OS) were performed. RESULTS: A total of 271 patients were included with a median follow-up of 149.9 months (range 140.1-159.9). complications CD ≥ II occurred in 162 (59.8%) patients, sepsis in 66 (22.5%), and intra-abdominal sepsis in 37 (13.6%). Recurrence developed in 88 (32.4%) patients. Independent predictors of short TTR were pTNM stage (IIIB-IIIC vs. IA-IIA) (hazard ratio [HR] = 37.55, 95% confidence interval [CI] 17.57-80.24; p < 0.001), D1 lymphadenectomy (HR = 3.14, 95% CI 1.94-5.07; p < 0.001), and male gender (HR = 1.65, 95% CI 1.06-2.57; p = 0.026). pTNM stage (IIIB-IIIC vs. IA-IIA, HR = 10.28, 95% CI 6.51-16.23; p < 0.001), male gender (HR = 1.64, 95% CI 1.17-2.31; p = 0.005), age (HR = 1.03, 95% CI 1.02-1.05; p < 0.001), and adjuvant therapy (HR = 0.55, 95% CI 0.37-0.83; p = 0.004) were identified as independent predictors of OS../nCONCLUSIONS: Evidence provided by this study does not support a negative impact of postoperative complications CD ≥ II, sepsis, and intra-abdominal sepsis on the oncologic outcome after curative gastric cancer resection.ca
dc.format.mimetype application/pdfca
dc.identifier.citation Climent M, Hidalgo N, Vidal Ó, Puig S, Iglesias M, Cuatrecasas M. et al. Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer. Eur J Surg Oncol. 2016 Jan;42(1):132-9. doi: 10.1016/j.ejso.2015.08.163.ca
dc.identifier.doi http://dx.doi.org/10.1016/j.ejso.2015.08.163
dc.identifier.issn 0748-7983
dc.identifier.uri http://hdl.handle.net/10230/25940
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof European Journal of Surgical Oncology. 2016 Jan;42(1):132-9
dc.rights c) 2015 Elsevier.Climent M, Hidalgo N, Vidal Ó, Puig S, Iglesias M, Cuatrecasas M. et al. Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer. Eur J Surg Oncol. 2016 Jan;42(1):132-9. doi: 10.1016/j.ejso.2015.08.163.ca
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Aparell digestiu -- Malaltiesca
dc.subject.other Gastroenterologiaca
dc.subject.other Aparell digestiu -- Càncerca
dc.title Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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