Association of maternal thyroglobulin with gestational thyroid function and offspring IQ and brain morphology

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Mulder, Tessa A.
  • dc.contributor.author Guxens Junyent, Mònica
  • dc.contributor.author Rebagliato, Marisa
  • dc.contributor.author Dineva, Mariana
  • dc.contributor.author Bath, Sarah C.
  • dc.contributor.author Hunziker, Sandra
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Delgado-Saborit, Juana Maria
  • dc.contributor.author Irizar, Amaia
  • dc.contributor.author Lertxundi, Nerea
  • dc.contributor.author Muetzel, Ryan L.
  • dc.contributor.author Tiemeier, Henning
  • dc.contributor.author Peeters, Robin P.
  • dc.contributor.author Korevaar, Tim I. M.
  • dc.date.accessioned 2025-09-19T07:35:21Z
  • dc.date.available 2025-09-19T07:35:21Z
  • dc.date.issued 2025
  • dc.description.abstract Background: Low maternal urinary iodine concentration (UIC) during pregnancy is associated with adverse offspring neurodevelopment. Thyroglobulin (Tg) has been suggested as a more sensitive biomarker than UIC of long-term iodine status, but associations of Tg with neurodevelopment and the possible mediating role of thyroid function remain unknown. Aim: To study whether maternal Tg is associated with (1) maternal and newborn thyroid function and (2) offspring IQ and brain morphology. Methods: Participants were selected from 2 population-based prospective cohorts: Generation R (the Netherlands, iodine-sufficient) and INfancia y Medio Ambiente (Spain, mildly iodine-deficient) with maternal Tg and thyroid function data in the first half of pregnancy or in cord blood, early childhood IQ (age 4.5 and 6 years), late childhood IQ (age 9 and 13), or brain morphology at 10 years. Associations of Tg with TSH, free T4 (FT4), IQ, and brain morphology were studied with multivariable linear regression. Results: (1) Tg was associated with lower TSH (-0.12 [-0.16; -0.08]) and higher FT4 (0.08 [0.05; 0.12]) in pregnancy (n = 4367) but not with cord blood TSH or FT4 (n = 2008). (2) Tg was associated with lower IQ in early childhood (β [95% confidence interval]: -0.06 [-0.10; -0.01], n = 2919) but not with IQ (n = 2503) or brain morphology (n = 1180) in later childhood. None of the associations of Tg with the studied outcomes differed by the iodine-to-creatinine ratio (ie, effect modification) or changed when adjusted for thyroid function. Conclusion: Higher Tg is associated with lower IQ in early childhood and higher thyroid function during pregnancy but not with IQ or brain morphology in later childhood. Further research should determine the value of Tg in addition to UIC for defining iodine status.
  • dc.description.sponsorship This study was funded by the Netherlands Organisation for Health Research and Development (ZonMw) VIDI Grant (project number 016.176.331, awarded to R.P.) and the Sophia Children's Hospital Foundation (SSWO, grant S17–19, awarded to T.K., H.T., and R.P.). The general design of the Generation R Study was made possible by financial support from the Erasmus Medical Center, Rotterdam, the Erasmus University Rotterdam, ZonMw, the Netherlands Organization for Scientific Research, and the Ministry of Health, Welfare, and Sport. This study was also supported in part by the EUthyroid Project: European Union's Horizon 2020 research and innovation program under grant agreement no. 634453. M.G. was funded by a Miguel Servet II fellowship (CPII18/00018) awarded by the Spanish Institute of Health Carlos III. We also acknowledge support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and support from the Generalitat de Catalunya through the CERCA Program. The INMA Project was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; FIS-FEDER:PI03/1615; PI041436; PI04/1509; PI06/1213; PI081151; PI11/01007; PI11/02591; PI11/02038; PI12/00610; PI12/01890; CP13/00054; PI13/1944; PI13/2032; PI14/00891; PI14/01687; PI16/1288; PI17/00663; PI19/1338; PII23/1578); Miguel Servet-FEDER (CP11/00178, CP15/00025, MSII16/00051, MS20/0006); CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241; Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822); Fundació La marató de TV3 (090430); Spanish Ministry of Economy and Competitiveness (SAF2012-32991 including FEDER funds); Spanish Ministry of Universities (Margarita Salas Grant MS21-133, grant CAS21/00008); Generalitat Valenciana (CIAICO/2021/132, BEST/2020/059, AICO 2020/285, AICO/2021/182, and CIDEGENT/2019/064); Consejo General de Enfermería (PNI22_CGE45); FISABIO (UGP 15-230, UGP-15-244, UGP-15-249); and Alicia Koplowitz Foundation 2017, Agence Nationale de Securite Sanitaire de l’Alimentation de l’Environnement et du Travail (1262C0010), EU Commission (261357, 308333, 603794 and 634453, FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, cod 874583, and cod 101136566).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Mulder TA, Guxens M, Rebagliato ML, Dineva M, Bath SC, Hunziker S, et al. Association of maternal thyroglobulin with gestational thyroid function and offspring IQ and brain morphology. J Clin Endocrinol Metab. 2025 Jun 17;110(7):2007-15. DOI: 10.1210/clinem/dgae679
  • dc.identifier.doi http://dx.doi.org/10.1210/clinem/dgae679
  • dc.identifier.issn 0021-972X
  • dc.identifier.uri http://hdl.handle.net/10230/71232
  • dc.language.iso eng
  • dc.publisher Oxford University Press
  • dc.relation.ispartof J Clin Endocrinol Metab. 2025 Jun 17;110(7):2007-15
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/603794
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/634453
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101136566
  • dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Brain development
  • dc.subject.keyword Iodine
  • dc.subject.keyword Thyroglobulin
  • dc.subject.keyword Thyroid function
  • dc.title Association of maternal thyroglobulin with gestational thyroid function and offspring IQ and brain morphology
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)