Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Zhang, Liye
• dc.contributor.author Marquès i Bonet, Tomàs, 1975-
• dc.contributor.author Roos, Christian
• dc.date.accessioned 2024-11-14T08:21:33Z
• dc.date.available 2024-11-14T08:21:33Z
• dc.date.issued 2024
• dc.description.abstract Many mammal species have declining populations, but the consequences of small population size on the genomic makeup of species remain largely unknown. We investigated the evolutionary history, genetic load and adaptive potential of the Cat Ba langur (Trachypithecus poliocephalus), a primate species endemic to Vietnam's famous Ha Long Bay and with less than 100 living individuals one of the most threatened primates in the world. Using high-coverage whole genome data of four wild individuals, we revealed the Cat Ba langur as sister species to its conspecifics of the northern limestone langur clade and found no evidence for extensive secondary gene flow after their initial separation. Compared to other primates and mammals, the Cat Ba langur showed low levels of genetic diversity, long runs of homozygosity, high levels of inbreeding and an excess of deleterious mutations in homozygous state. On the other hand, genetic diversity has been maintained in protein-coding genes and on the gene-rich human chromosome 19 ortholog, suggesting that the Cat Ba langur retained most of its adaptive potential. The Cat Ba langur also exhibits several unique non-synonymous variants that are related to calcium and sodium metabolism, which may have improved adaptation to high calcium intake and saltwater consumption.
• dc.description.sponsorship We thank Tran Van Lan, Nguyen Ba Tiep, Hoang Van Thap, Nguyen Van Phien, Vu Hong Van, Alexandra Kolodyazhnaya, and Michael Meyerhoff for logistic support and help with data analysis, and Stephan D. Nash for permission to use his langur illustrations. We are grateful to the Cat Ba langur Conservation Project, Zoo Leipzig, Allwetterzoo Münster, the Zoologische Gesellschaft für Arten- und Populationsschutz, the Endangered Primate Rescue Center, Cat Ba National Park, Cuc Phuong National Park and the Ministry for Agricultural and Rural Development for continuous support. Financial support for this research was provided by grants from the German Research Foundation (HO 3492/9-1 to M.H. and RO 3055/7-1 to C.R.), Sino-German Mobility Programme (M-0084 to M.Li and C.R.), Chinese Academy of Sciences (CAS XDB31000000 to M.Li) and National Natural Science Foundation of China (NSFC 31821001 to M.Li) and Vietnamese Ministry of Science and Technology’s Program 562 (ĐTĐL.CN-64/19 to M.D.L.). T.M.-B. was supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 864203), PID2021-126004NB-100 (MICIIN/FEDER, UE), “Unidad de Excelencia María de Maeztu”, funded by the AEI (CEX2018-000792-M), NIH 1R01HG010898-01A1 and Secretaria d’Universitats i Recerca and CERCA Programme del Departament d’Economia i Coneixement de la Generalitat de Catalunya (GRC 2021 SGR 00177).
• dc.format.mimetype application/pdf
• dc.identifier.citation Zhang L, Leonard N, Passaro R, Luan MS, Van Tuyen P, Han LTN, et al. Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur. Nat Commun. 2024 Oct 2;15(1):8531. DOI: 10.1038/s41467-024-52811-7
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-024-52811-7
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/68522
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2024 Oct 2;15(1):8531
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-126004NB-100
• dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Animal physiology
• dc.subject.keyword Evolutionary biology
• dc.subject.keyword Evolutionary ecology
• dc.subject.keyword Evolutionary genetics
• dc.title Genomic adaptation to small population size and saltwater consumption in the critically endangered Cat Ba langur
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion