TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export

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• dc.contributor.author Santos, António J. M.
• dc.contributor.author Raote, Ishier
• dc.contributor.author Scarpa, Margherita
• dc.contributor.author Brouwers, Nathalie
• dc.contributor.author Malhotra, Vivek
• dc.date.accessioned 2025-01-13T08:34:44Z
• dc.date.available 2025-01-13T08:34:44Z
• dc.date.issued 2015
• dc.description.abstract Previously we showed that membrane fusion is required for TANGO1-dependent export of procollagen VII from the endoplasmic reticulum (ER) (Nogueira, et al., 2014). Along with the t-SNARE Syntaxin 18, we now reveal the complete complement of SNAREs required in this process, t-SNAREs BNIP1 and USE1, and v-SNARE YKT6. TANGO1 recruits YKT6-containing ER Golgi Intermediate Compartment (ERGIC) membranes to procollagen VII-enriched patches on the ER. Moreover residues 1214-1396, that include the first coiled coil of TANGO1, specifically recruit ERGIC membranes even when targeted to mitochondria. TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the ER. Our data reveal that growth of a mega transport carrier for collagen export from the ER is not by acquisition of a larger patch of ER membrane, but instead by addition of ERGIC membranes to procollagen-enriched domains of the ER by a TANGO1-mediated process.en
• dc.description.sponsorship European Commission (European Union Seventh Framework Programme (FP7/2007-2013) 625149). Ministerio de Economía y Competitividad (SEV-2012-0208). Ministerio de Economía y Competitividad (Plan Nacional BFU2013-44188-P). European Research Council (Consolider CSD2009-00016).en
• dc.format.mimetype application/pdf
• dc.identifier.citation Santos AJ, Raote I, Scarpa M, Brouwers N, Malhotra V. TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export. eLife. 2015 Nov 14;4:e10982. DOI: 10.7554/eLife.10982
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.10982
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/69061
• dc.language.iso eng
• dc.publisher eLife
• dc.relation.ispartof eLife. 2015 Nov 14;4:e10982
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/625149
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2013-44188-P
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/609989
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SEV-2012-0208
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/CSD2009-00016
• dc.rights © 2015, Santos et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.other Reticle endoplasmàticca
• dc.subject.other Fusió membranàriaca
• dc.subject.other Membranes cel·lularsca
• dc.title TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion