Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the rhea pregnancy cohort crete, Greece.
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- dc.contributor.author Daraki, Vasilikica
- dc.contributor.author Georgiou, Vaggelisca
- dc.contributor.author Papavasiliou, Stathisca
- dc.contributor.author Chalkiadaki, Georgiaca
- dc.contributor.author Karachaliou, Mariannaca
- dc.contributor.author Koinaki, Stellaca
- dc.contributor.author Sarri, Katerinaca
- dc.contributor.author Vassilaki, Mariaca
- dc.contributor.author Kogevinas, Manolisca
- dc.contributor.author Chatzi, Ledaca
- dc.date.accessioned 2015-05-26T10:52:27Z
- dc.date.available 2015-05-26T10:52:27Z
- dc.date.issued 2015
- dc.description.abstract CONTEXT: Maternal pre-pregnancy obesity may increase the risk of childhood obesity but it is unknown whether other metabolic factors in early pregnancy such as lipid profile and hypertension are associated with offspring cardiometabolic traits. OBJECTIVE: Our objective was to investigate whether fasting lipid, glucose, and insulin levels during early pregnancy and maternal pre-pregnancy weight status, are associated with offspring adiposity measures, lipid levels and blood pressure at preschool age. DESIGN AND METHODS: The study included 618 mother-child pairs of the pregnancy cohort "Rhea" study in Crete, Greece. Pregnant women were recruited at the first prenatal visit (mean: 12weeks, SD: 0.7). A subset of 348 women provided fasting serum samples for glucose and lipid measurements. Outcomes measures were body mass index, abdominal circumference, sum of skinfold thickness, and blood pressure measurements at 4 years of age. A subsample of 525 children provided non-fasting blood samples for lipid measurements. RESULTS: Pre-pregnancy overweight/obesity was associated with greater risk of offspring overweight/obesity (RR: 1.83, 95%CI: 1.19, 2.81), central adiposity (RR: 1.97, 95%CI: 1.11, 3.49), and greater fat mass by 5.10mm (95%CI: 2.49, 7.71) at 4 years of age. These associations were more pronounced in girls. An increase of 40mg/dl in fasting serum cholesterol levels in early pregnancy was associated with greater skinfold thickness by 3.30mm (95%CI: 1.41, 5.20) at 4 years of age after adjusting for pre-pregnancy BMI and several other confounders. An increase of 10mmHg in diastolic blood pressure in early pregnancy was associated with increased risk of offspring overweight/obesity (RR: 1.22, 95%CI: 1.03, 1.45), and greater skinfold thickness by 1.71mm (95% CI: 0.57, 2.86) at 4 years of age./nCONCLUSIONS: Metabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age.ca
- dc.description.sponsorship Rhea project was financially supported by European projects (EU FP6-2003-Food-3- NewGeneris, EU FP6. STREP Hiwate, EU FP7
- dc.description.sponsorship Rhea project was financially supported byEuropean projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7. ENV.2007.1.2.2.2. Project No 211250 Escape, EUFP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO,EU- FP7- HEALTH-2012 Proposal No 308333HELIX) and the Greek Ministry of Health (Program ofPrevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district,Crete, Greece: 2011-2014;“Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15)
- dc.format.mimetype application/pdfca
- dc.identifier.citation Daraki V, Georgiou V, Papavasiliou S, Chalkiadaki G, Karahaliou M, Koinaki S. et al. Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the rhea pregnancy cohort crete, Greece. PLoS One. 2015 May 13;10(5):e0126327. doi: 10.1371/journal.pone.0126327. eCollection 2015.ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0126327. eCollection 2015
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/23653
- dc.language.iso engca
- dc.publisher Public Library of Scienceca
- dc.relation.ispartof PLoS ONE. 2015 May 13;10(5):e0126327
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
- dc.rights © 2015 Daraki et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source arecredited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Embaràsca
- dc.subject.other Obesitatca
- dc.title Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the rhea pregnancy cohort crete, Greece.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca