Cannabis use induces distinctive proteomic alterations in olfactory neuroepithelial cells of schizophrenia patients
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- dc.contributor.author Barrera Conde, Marta
- dc.contributor.author Ausín, Karina
- dc.contributor.author Lachén Montes, Mercedes
- dc.contributor.author Fernández Irigoyen, Joaquín
- dc.contributor.author Galindo Guarín, Liliana
- dc.contributor.author Cuenca Royo, Aida Ma, 1981-
- dc.contributor.author Fernández Avilés, Cristina
- dc.contributor.author Pérez, Victor
- dc.contributor.author Torre Fornell, Rafael de la
- dc.contributor.author Santamaría, Enrique
- dc.contributor.author Robledo, Patricia, 1958-
- dc.date.accessioned 2021-04-09T06:45:53Z
- dc.date.available 2021-04-09T06:45:53Z
- dc.date.issued 2021
- dc.description.abstract A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared the proteomic profiles of SCZ non-cannabis users (SCZ/nc) and SCZ cannabis users (SCZ/c) with control subjects non-cannabis users (C/nc) and control cannabis users (C/c). The results revealed that the main cascades affected in SCZ/nc were cell cycle, DNA replication, signal transduction and protein localization. Conversely, cannabis use in SCZ patients induced specific alterations in metabolism of RNA and metabolism of proteins. The levels of targeted proteins in each population were then correlated with cognitive performance and clinical scores. In SCZ/c, the expression levels of 2 proteins involved in the metabolism of RNA (MTREX and ZNF326) correlated with several cognitive markers and clinical signs. Moreover, use duration of cannabis negatively correlated with ZNF326 expression. These findings indicate that RNA-related proteins might be relevant to understand the influence of cannabis use on SCZ.
- dc.format.mimetype application/pdf
- dc.identifier.citation Barrera-Conde M, Ausin K, Lachén-Montes M, Fernández-Irigoyen J, Galindo L, Cuenca-Royo A, Fernández-Avilés C, Pérez V, de la Torre R, Santamaría E, Robledo P. Cannabis use induces distinctive proteomic alterations in olfactory neuroepithelial cells of schizophrenia patients. J Pers Med. 2021; 11(3):160. DOI: 10.3390/jpm11030160
- dc.identifier.doi http://dx.doi.org/10.3390/jpm11030160
- dc.identifier.issn 2075-4426
- dc.identifier.uri http://hdl.handle.net/10230/47065
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof J Pers Med. 2021; 11(3):160
- dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword MTREX
- dc.subject.keyword RNA
- dc.subject.keyword ZNF326
- dc.subject.keyword Cannabis
- dc.subject.keyword Metabolism
- dc.subject.keyword Olfactory neuroepithelium
- dc.subject.keyword Proteomics
- dc.subject.keyword Schizophrenia
- dc.title Cannabis use induces distinctive proteomic alterations in olfactory neuroepithelial cells of schizophrenia patients
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion