The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription. Journal of cell science
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Stanisavljević, Jelena, 1981-ca
- dc.contributor.author Porta de la Riva, Montserratca
- dc.contributor.author Batlle Gómez, Raquelca
- dc.contributor.author García de Herreros, Antonioca
- dc.contributor.author Baulida i Estadella, Josep, 1965-ca
- dc.date.accessioned 2015-12-18T19:08:27Z
- dc.date.available 2015-12-18T19:08:27Z
- dc.date.issued 2011
- dc.description.abstract Snail1 is a transcriptional repressor of E-cadherin that triggers epithelial-mesenchymal transition (EMT). Here, we report assisted Snail1 interaction with the promoter of a typical mesenchymal gene, fibronectin (FN1), both in epithelial cells undergoing EMT and in fibroblasts. Together with Snail1, the p65 subunit of NF-κB and PARP1 bound to the FN1 promoter. We detected nuclear interaction of these proteins and demonstrated the requirement of all three for FN1 transcription. Moreover, other genes involved in cell movement mimic FN1 expression induced by Snail1 or TGF-β1 treatment and recruit p65NF-κB and Snail1 to their promoters. The molecular cooperation between Snail1 and NF-κB in transcription activation provides a new insight into how Snail1 can modulate a variety of cell programs.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Stanisavljevic J, Porta-de-la-Riva M, Batlle R, de Herreros AG, Baulida J. The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription. Journal of cell science. 2011; 124(Pt 24): 4161-4171. DOI 10.1242/jcs.078824ca
- dc.identifier.doi http://dx.doi.org/10.1242/jcs.078824
- dc.identifier.issn 0021-9533
- dc.identifier.uri http://hdl.handle.net/10230/25479
- dc.language.iso engca
- dc.publisher Company of Biologistsca
- dc.relation.ispartof Journal of cell science. 2011; 124(Pt 24): 4161-4171
- dc.rights © Company of Biologists http://jcs.biologists.org/content/124/24/4161.long DOI 10.1242/jcs.078824ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Snail1
- dc.subject.keyword p65NF-kB
- dc.subject.keyword PARP1
- dc.subject.keyword Epithelial–mesenchymal transition
- dc.subject.keyword E-cadherin
- dc.subject.keyword Fibronectin
- dc.subject.other Factors de transcripcióca
- dc.title The p65 subunit of NF-κB and PARP1 assist Snail1 in activating fibronectin transcription. Journal of cell scienceca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca