Unique transcriptomes of sensory and non-sensory neurons: insights from Splicing Regulatory States

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  • dc.contributor.author Ciampi, Ludovica
  • dc.contributor.author Serrano Pubull, Luis, 1982-
  • dc.contributor.author Irimia Martínez, Manuel
  • dc.date.accessioned 2024-04-18T05:45:45Z
  • dc.date.available 2024-04-18T05:45:45Z
  • dc.date.issued 2024
  • dc.description.abstract Alternative Splicing (AS) programs serve as instructive signals of cell type specificity, particularly within the brain, which comprises dozens of molecularly and functionally distinct cell types. Among them, retinal photoreceptors stand out due to their unique transcriptome, making them a particularly well-suited system for studying how AS shapes cell type-specific molecular functions. Here, we use the Splicing Regulatory State (SRS) as a novel framework to discuss the splicing factors governing the unique AS pattern of photoreceptors, and how this pattern may aid in the specification of their highly specialized sensory cilia. In addition, we discuss how other sensory cells with ciliated structures, for which data is much scarcer, also rely on specific SRSs to implement a proteome specialized in the detection of sensory stimuli. By reviewing the general rules of cell type- and tissue-specific AS programs, firstly in the brain and subsequently in specialized sensory neurons, we propose a novel paradigm on how SRSs are established and how they can diversify. Finally, we illustrate how SRSs shape the outcome of mutations in splicing factors to produce cell type-specific phenotypes that can lead to various human diseases.
  • dc.description.sponsorship We acknowledge the support of the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa (CEX2020-001049-S, MCIN/AEI/10.13039/501100011033), and the Generalitat de Catalunya through the CERCA programme. This work has been funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (ERC-CoG-LS2-101002275 to MI), the Spanish Ministerio de Ciencia (BFU2017-89201-P to MI and PGC2018-101271-B-I00 to LS).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Ciampi L, Serrano L, Irimia M. Unique transcriptomes of sensory and non-sensory neurons: insights from Splicing Regulatory States. Mol Syst Biol. 2024 Apr;20(4):296-310. DOI: 10.1038/s44320-024-00020-1
  • dc.identifier.doi http://dx.doi.org/10.1038/s44320-024-00020-1
  • dc.identifier.issn 1744-4292
  • dc.identifier.uri http://hdl.handle.net/10230/59816
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.ispartof Mol Syst Biol. 2024 Apr;20(4):296-310
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101002275
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2020-001049-S
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89201-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101271-B-I00
  • dc.rights © 2024 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Alternative splicing
  • dc.subject.keyword Cell types
  • dc.subject.keyword Photoreceptors
  • dc.subject.keyword Regulatory states
  • dc.subject.keyword Sensory neurons
  • dc.title Unique transcriptomes of sensory and non-sensory neurons: insights from Splicing Regulatory States
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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