The association of Helicobacter pylori with adverse pregnancy outcomes in three European birth cohorts

Galan, Raquel; Pembrey, Lucy; Bustamante Pineda, Mariona; Aguilar, Ruth; Mason, Dan; Vidal, Marta; Bañuls, Marc; Roumeliotaki, Theano; Delgado-Saborit, Juana Maria; Marin, Natalia; Vrijheid, Martine; Bempi, Vicky; Moncunill, Gemma; Dobaño, Carlota; Kogevinas, Manolis; Karachaliou, Marianna

The association of Helicobacter pylori with adverse pregnancy outcomes in three European birth cohorts

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dc.contributor.author Galan, Raquel
dc.contributor.author Pembrey, Lucy
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Aguilar, Ruth
dc.contributor.author Mason, Dan
dc.contributor.author Vidal, Marta
dc.contributor.author Bañuls, Marc
dc.contributor.author Roumeliotaki, Theano
dc.contributor.author Delgado-Saborit, Juana Maria
dc.contributor.author Marin, Natalia
dc.contributor.author Vrijheid, Martine
dc.contributor.author Bempi, Vicky
dc.contributor.author Moncunill, Gemma
dc.contributor.author Dobaño, Carlota
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Karachaliou, Marianna
dc.date.accessioned 2025-01-15T07:25:29Z
dc.date.available 2025-01-15T07:25:29Z
dc.date.issued 2024
dc.description.abstract Background: Helicobacter pylori is a prevalent infection that may complicate pregnancy, but evidence remains limited, controversial and may not apply to all pregnant women. Objective: This study aims to evaluate whether Helicobacter pylori is a risk factor for adverse pregnancy outcomes and to identify vulnerable subpopulations. Study design: Multiplex serology was utilized to measure blood levels of immunoglobulin G against eight Helicobacter pylori antigens in 1372 pregnant women from three European birth cohorts: BiB (United Kingdom), Rhea (Greece) and INMA (Spain). Outcomes of interest included gestational diabetes mellitus, gestational hypertension, preeclampsia, preterm birth and small for gestational age neonates, as well as prenatal anxiety and depression. Adjusted logistic regression models were used to evaluate the association between Helicobacter pylori seropositivity (overall and by antigen) and antigen specific antibody levels with the outcomes. We examined effect modification of the associations by ethnicity. Results: Helicobacter pylori seropositivity was detected in 18.8% (258/1372) of pregnant women. Preeclampsia was the least common outcome (26/830). Helicobacter pylori seropositivity was associated with the development of two or more adverse pregnancy outcomes (gestational hypertension, gestational diabetes, preterm birth, small gestational age and preeclampsia) [OR:1.32 (95% CI: 1.06-1.65), p-value: 0.01], especially in women with high antibody levels to OMP antigen [OR: 2.12 (95% CI: 1.62-2.76), p-value: 0.001]. Women with high antibody levels to Helicobacter pylori antigens GroEL and NapA were more likely to develop preeclampsia [OR: 2.34 (95% CI: 1.10-8.82), p-value: 0.03; OR: 4.09 (95% CI: 1.4-11.93), p-value 0.01)]. Helicobacter pylori seropositivity increased the odds of developing any hypertensive disorder during pregnancy among women of western ethnicity (948/1372) [OR:3.35 (95% CI: 1.29-8.74), p-value 0.03]. Conclusion: Our study suggests that Helicobacter pylori seropositivity is a risk factor for multiple adverse pregnancy outcomes and particularly in women of western origin for hypertensive disorders during pregnancy. Moreover, pathogen specific characteristics reflected in the antibody responses against OMP, GroEL and NapA seem to determine disease associations.
dc.description.sponsorship This work has been founded by La Mataró de TV3 2017 (project num- ber 201819, Reg. 78/437). The INMA Sabadell cohort has been funded by the Instituto de Salud Carlos III (Red INMA G03/176) and Generalidad de Catalunya-CIRIT 1999SGR 00241. The Rhea project has been financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6-STREP-Hiwate, EUFP7-ENV.2007.1.2.2.2.- no.211250-Escape, EUFP7-2008-ENV-1.2.1.4-Envirogenomarkers, EUFP7-HEALTH-2009-single stage-CHICOS, EUFP7ENV.2008.1.2.1.6.-no. 226285-ENRIECO, EU FP7-HEALTH-2012-no. 308333-HELIX, EU FP7-no. 264357 EU H2020 No. 733206, LIFE-CYCLE) and the Greek Ministry of Health (NSRF no. 34958 and no. 365462). Born in Bradford receives funding from the Wellcome Trust (WT101597MA) and from the UK Medical Research Council (MRC) and Economic and Social Science Research Council (ESRC) (MR/N024397/1). ISGlobal receives support from the Spanish Ministry of Science and Innovation (“Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX 2018‐000806‐S), the grant CEX2018-000806-S funded by https://sites.google.com/site/nonlineardynamicsevolutionlab/funding and from the Generalitat de Catalunya through the CERCA Program.
dc.format.mimetype application/pdf
dc.identifier.citation Galan R, Pembrey L, Bustamante M, Aguilar R, Mason D, Vidal M, et al. The association of Helicobacter pylori with adverse pregnancy outcomes in three European birth cohorts. BMC Pregnancy Childbirth. 2024 Nov 12;24(1):745. DOI: 10.1186/s12884-024-06901-5
dc.identifier.doi http://dx.doi.org/10.1186/s12884-024-06901-5
dc.identifier.issn 1471-2393
dc.identifier.uri http://hdl.handle.net/10230/69129
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Pregnancy Childbirth. 2024 Nov 12;24(1):745
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Helicobacter pylori
dc.subject.keyword Cohort
dc.subject.keyword Ethnicity
dc.subject.keyword Europe
dc.subject.keyword Hypertension
dc.subject.keyword Preeclampsia
dc.subject.keyword Pregnancy outcomes
dc.title The association of Helicobacter pylori with adverse pregnancy outcomes in three European birth cohorts
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Hospital del Mar Research Institute)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)