Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula

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• dc.contributor.author Pimenta, João
• dc.contributor.author Lopes, Alexandra M.
• dc.contributor.author Carracedo, Ángel
• dc.contributor.author Arenas, Miguel
• dc.contributor.author Amorim, António
• dc.contributor.author Comas, David, 1969-
• dc.date.accessioned 2019-09-05T15:58:04Z
• dc.date.available 2019-09-05T15:58:04Z
• dc.date.issued 2019
• dc.description.abstract The Iberian Peninsula is a well-delimited geographic region with a rich and complex human history. However, the causes of its genetic structure and past migratory dynamics are not yet fully understood. In order to shed light on them, here we evaluated the gene flow and genetic structure throughout the Iberian Peninsula with spatially explicit modelling applied to a georeferenced genetic dataset composed of genome-wide SNPs from 746 individuals belonging to 17 different regions of the Peninsula. We found contrasting patterns of genetic structure throughout Iberia. In particular, we identified strong patterns of genetic differentiation caused by relevant barriers to gene flow in northern regions and, on the other hand, a large genetic similarity in central and southern regions. In addition, our results showed a preferential north to south migratory dynamics and suggest a sex-biased dispersal in Mediterranean and southern regions. The estimated genetic patterns did not fit with the geographical relief of the Iberian landscape and they rather seem to follow political and linguistic territorial boundaries.
• dc.description.sponsorship IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). J.P. and A.M.L. are funded by the Portuguese Government through the FCT fellowship SFRH/BD/97200/2013 and the research contract IF/01262/2014, respectively. M.A. was supported by the “Ramón y Cajal” grant RYC-2015-18241 from the Spanish Government. D.C. was supported by the Spanish grant CGL2016-75389-P (AEI, MINEICO/FEDER, UE), and “Unidad María de Maeztu” funded by the MINECO (MDM-2014-0370).
• dc.format.mimetype application/pdf
• dc.identifier.citation Pimenta J, Lopes AM, Carracedo A, Arenas M, Amorim A, Comas D. Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula. Sci Rep. 2019; 9(1):7825. DOI: 10.1038/s41598-019-44121-6
• dc.identifier.doi http://dx.doi.org/10.1038/s41598-019-44121-6
• dc.identifier.issn 2045-2322
• dc.identifier.uri http://hdl.handle.net/10230/42245
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Scientific Reports. 2019; 9(1):7825
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-P
• dc.rights © The Author(s) 2019. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biological anthropology
• dc.subject.keyword Genetic variation
• dc.title Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion