Sex differences in the comorbidity of patients seeking a first treatment for Alcohol Use Disorder

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• dc.contributor.author García-Marchena, Nuria
• dc.contributor.author Sanvisens, Arantza
• dc.contributor.author Abellí-Deulofeu, Enric
• dc.contributor.author Blanes, Rafael
• dc.contributor.author Torrens, Marta
• dc.contributor.author Miquel, Laia
• dc.contributor.author Rubio, Gabriel
• dc.contributor.author Bolao, Ferran
• dc.contributor.author Muga, Roberto
• dc.contributor.author CohRTA Study
• dc.date.accessioned 2025-02-03T15:19:03Z
• dc.date.available 2025-02-03T15:19:03Z
• dc.date.issued 2023
• dc.description Data de publicació electrònica: 20-07-2023
• dc.description.abstract Background: The CohRTA multicenter study aims to characterize patients undergoing a first treatment for alcohol use disorder (AUD). The objective is to analyze sex-specific differences in the comorbidity of AUD when starting the first treatment for the disorder. Methods: A multicenter study was carried out between 2014 and 2021 in 6 public centers in Spain. Sociodemographic characteristics were collected, variables related to alcohol consumption, medical comorbidity according to Cumulative Illness Rating Scale-Substance Abuse (CIRS-SA), antecedent of psychiatric comorbidity, general blood test and screening for drugs in urine. Logistic regression models were used to establish associations. Results: A total of 896 patients (634 M, 262 W) were included. Median age at admission was 48 years [IQR:41–56 years]. Men reported beginning regular alcohol consumption at an earlier age and drank more alcohol. The most frequent medical comorbidities were hepatic, respiratory, vascular and neurological. The median number of affected systems was three, with no differences between men and women. However, depressive disorder was more frequent in women. In the multivariate analysis, women were up to 4 times more likely to have a major depressive disorder, elevated ESR and elevated total cholesterol than men. Men started alcohol consumption earlier, had a higher body mass index (BMI), a higher probability of using cocaine and a higher frequency of GGT and bilirubin alteration than women. Conclusion: Differences by sex were found among individuals beginning first treatment for AUD. These differences must be taken into account when designing specific therapeutic strategies for men and women.
• dc.format.mimetype application/pdf
• dc.identifier.citation García-Marchena N, Sanvisens A, Abellí-Deulofeu E et al. Sex differences in the comorbidity of patients seeking a first treatment for Alcohol Use Disorder. Int J Ment Health Addiction. 2023. DOI: 10.1007/s11469-023-01112-z
• dc.identifier.doi http://dx.doi.org/10.1007/s11469-023-01112-z
• dc.identifier.issn 1557-1874
• dc.identifier.uri http://hdl.handle.net/10230/69458
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Int J Ment Health Addiction. 2023
• dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Alcohol
• dc.subject.keyword Sex differences
• dc.subject.keyword Clinical variables
• dc.subject.keyword Comorbid disorders
• dc.title Sex differences in the comorbidity of patients seeking a first treatment for Alcohol Use Disorder
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion