Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Adam, Martinca
• dc.contributor.author Carsin, Anne-Elieca
• dc.contributor.author Jacquemin Leonard, Bénédicteca
• dc.contributor.author Cirach, Martaca
• dc.contributor.author Nieuwenhuijsen, Mark J.ca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Probst-Hensch, Nicoleca
• dc.date.accessioned 2016-04-26T14:38:33Z
• dc.date.available 2016-04-26T14:38:33Z
• dc.date.issued 2015
• dc.description.abstract The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO₂, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV₁) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO₂ exposure was associated with lower levels of FEV₁ (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV₁ (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.ca
• dc.description.sponsorship ECRHS was supported by the European Commission, as part of their Quality of Life program. The coordination of ECRHS II was supported by the European Commission, as part of their Quality of Life programme. The following bodies funded the local studies in ECRHS II in this article: Albacete-Fondo de Investigaciones Santarias (grant code: 97/0035-01, 13 99/0034-01, and 99/0034-02) (Hospital Universitario de Albacete, Consejeria de Sanidad); Antwerp-FWO Fund for Scientific Research), Flanders, Belgium (grant code: G.0402.00) (University of Antwerp, Flemish Health Ministry); Barcelona-Fondo de Investigaciones Sanitarias (grant code: 99/0034-01, and 99/0034-02), Red Respira (RTIC 03/11 ISC IIF); Ciber of Epidemiology and Public Health was established and founded by Instituto de Salud Carlos III; Erfurt-GSF–National Research Centre for Environment and Health, Deutsche Forschungsgemeinschaft (DFG) (grant code FR 1526/1-1); Galdakao-Basque Health Department; Grenoble-Programme Hospitalier de Recherche Clinique-DRC de Grenoble 2000 no.2610, Ministry of Health, Direction de la Recherche Clinique, Ministere de l’Emploi et de la Solidarite, Direction Generale de la Sante, CHU de Grenoble, Comite des Maladies Respiratoires de l’Isere; Ipswich and Norwich-National Asthma Campaign (UK); Huelva-Fondo de Investigaciones Sanitarias (FIS) (grant code:/n97/0035-01, 99/0034-01, and 99/0034-02); Oviedo-Fondo de Investigaciones Santarias (FIS) (grant code: 97/0035-01, 99//n0034-01, and 99/0034-02); Paris-Ministere de l’Emploi et de la Solidarite, Direction Generale de la Sante, UCBPharma/n(France), Aventis (France), Glaxo France, Programme Hospitalier de Recherche Clinique-DRC de Grenoble 2000 no. 2610, Ministry of Health, Direction de la Recherche Clinique, CHU de Grenoble; measurements and models for PM in Grenoble (ECRHS) were funded by Region Rhônes-Alpes; Pavia-Glaxo, Smith and Kline Italy, Italian Ministry of University and Scientific and Technological Research (MURST), Local University Funding for Research 1998 and 1999 (Pavia, Italy); Turin-ASL 4 Regione Piemonte (Italy), AO CTO/ICORMA Regione Piemonte (Italy), Ministero dell’Università e della Ricerca Scientifica (Italy), Glaxo Wellcome spa (Verona, Italy); Umeå-Swedish Heart Lung Foundation, Swedish Foundation for Health Care Sciences and Allergy Research, Swedish Asthma and Allergy Foundation, Swedish Cancer and Allergy Foundation; Verona-University of Verona; Italian Ministry of University and Scientific and Technological Research (MURST); Glaxo, Smith and Kline Italy. EGEA is funded in part by PHRC-Paris, PHRC-Grenoble, ANR 05-SEST-020-02/05-9-97, ANR-06-CEBS, ANRCES-2009, Région Nord Pas-de-Calais, Merck Sharp and Dohme (MSD). NSHD and Profs R. Hardy and D. Kuh are supported by core funding and grant funding (U1200632239 and/nU12309272) from the UK Medical Research Council. The authors acknowledge the NSHD participants and the NSHD/nscientific and data collection teams. SALIA received funds from the German state (NRW) and federal Ministries of the Environment. The follow-up investigation was funded by the DGUV (German statutory accident assurance) VT 266.1. SAPALDIA received funds from the Swiss National Science Foundation (grants no 33CSCO-134276/1, 33CSCO-108796, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099), the Federal Office for Forest, Environment and Landscape and several Federal and Cantonal authorities.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Adam M, Schikowski T, Carsin AE, Cai Y, Jacquemin B, Sanchez M et al. Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. The European respiratory journal. 2015; 123(6): 613-621. DOI 10.1289/ehp.1408206ca
• dc.identifier.doi http://dx.doi.org/10.1289/ehp.1408206
• dc.identifier.issn 0903-1936
• dc.identifier.uri http://hdl.handle.net/10230/26176
• dc.language.iso engca
• dc.publisher European Respiratory Societyca
• dc.relation.ispartof Environmental health perspectives. 2015; 123(6): 613-621
• dc.rights © ERS 2015. ERJ Open articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/ca
• dc.subject.other Aire -- Contaminacióca
• dc.subject.other Pulmons -- Fisiologia patològicaca
• dc.title Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysisca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca