Hunger and satiety peptides: is there a pattern to classify patients with prader-Willi syndrome?

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• dc.contributor.author Bueno, Marta
• dc.contributor.author Boixadera-Planas, Ester
• dc.contributor.author Blanco Hinojo, Laura, 1981-
• dc.contributor.author Esteba-Castillo, Susanna
• dc.contributor.author Giménez Palop, Olga
• dc.contributor.author Torrents-Rodas, David
• dc.contributor.author Pujol Martí, Jesús, 1981-
• dc.contributor.author Corripio, Raquel
• dc.contributor.author Deus, Joan
• dc.contributor.author Caixàs, Assumpta
• dc.date.accessioned 2022-11-15T08:29:42Z
• dc.date.available 2022-11-15T08:29:42Z
• dc.date.issued 2021
• dc.description.abstract Hyperphagia is one of the main problems of patients with Prader-Willi syndrome (PWS) to cope with everyday life. The underlying mechanisms are not yet well understood. Gut-brain hormones are an interrelated network that may be at least partially involved. We aimed to study the hormonal profile of PWS patients in comparison with obese and healthy controls. Thirty adult PWS patients (15 men; age 27.5 ± 8.02 years; BMI 32.4 ± 8.14 kg/m2), 30 obese and 30 healthy controls were studied before and after eating a hypercaloric liquid diet. Plasma brain-derived neurotrophic factor (BDNF), leptin, total and active ghrelin, peptide YY (PYY), pancreatic polypeptide (PP), Glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and amylin were determined at times 0', 30', 60' and 120'. Cluster analysis was used. When considering all peptides together, two clusters were established according to fasting hormonal standardized concentrations. Cluster 1 encompassed most of obese (25/30) and healthy controls (28/30). By contrast, the majority of patients with PWS were located in Cluster 2 (23/27) and presented a similar fasting profile with hyperghrelinemia, high levels of leptin, PYY, GIP and GLP-1, compared to Cluster 1; that may reflect a dysfunction of these hunger/satiety hormones. When peptide behavior over the time was considered, PP concentrations were not sustained postprandially from 60 min onwards in Cluster 2. BDNF and amylin did not help to differentiate the two clusters. Thus, cluster analysis could be a good tool to distinguish and characterize the differences in hormone responses between PWS and obese or healthy controls.
• dc.format.mimetype application/pdf
• dc.identifier.citation Bueno M, Boixadera-Planas E, Blanco-Hinojo L, Esteba-Castillo S, Giménez-Palop O, Torrents-Rodas D, et al. Hunger and satiety peptides: is there a pattern to classify patients with prader-Willi syndrome? J Clin Med. 2021 Nov 4; 10(21): 5170. DOI: 10.3390/jcm10215170.
• dc.identifier.doi http://dx.doi.org/10.3390/jcm10215170
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/54851
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2021 by Bueno M, Boixadera-Planas E, Blanco-Hinojo L, Esteba-Castillo S, Giménez-Palop O, Torrents-Rodas D, et al. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword BDNF
• dc.subject.keyword PYY
• dc.subject.keyword Prader-Willi syndrome
• dc.subject.keyword Clusters
• dc.subject.keyword Ghrelin
• dc.subject.keyword Hunger
• dc.subject.keyword Obesity
• dc.subject.keyword Satiety
• dc.title Hunger and satiety peptides: is there a pattern to classify patients with prader-Willi syndrome?
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion