Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Rouxel, Elke; Costet, Nathalie; Monfort, Christine; Audouze, Karine; Cirugeda, Lourdes; Gaudreau, Eric; Grimalt Obrador, Joan; Ibarluzea, Jesús; Lainé, Fabrice; Llop, Sabrina; Lopez-Espinosa, Maria-José; Rouget, Florence; Santa Marina, Loreto; Vrijheid, Martine; Chevrier, Cécile; Casas Sanahuja, Maribel; Warembourg, Charline

Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Rouxel, Elke
dc.contributor.author Costet, Nathalie
dc.contributor.author Monfort, Christine
dc.contributor.author Audouze, Karine
dc.contributor.author Cirugeda, Lourdes
dc.contributor.author Gaudreau, Eric
dc.contributor.author Grimalt Obrador, Joan
dc.contributor.author Ibarluzea, Jesús
dc.contributor.author Lainé, Fabrice
dc.contributor.author Llop, Sabrina
dc.contributor.author Lopez-Espinosa, Maria-José
dc.contributor.author Rouget, Florence
dc.contributor.author Santa Marina, Loreto
dc.contributor.author Vrijheid, Martine
dc.contributor.author Chevrier, Cécile
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Warembourg, Charline
dc.date.accessioned 2023-11-07T07:28:16Z
dc.date.available 2023-11-07T07:28:16Z
dc.date.issued 2023
dc.description.abstract Background: Several studies have reported that prenatal exposure to some persistent organic pollutants (POPs) is associated with higher adiposity in childhood. Few studies have assessed whether this finding persists into adolescence, and few have considered exposure to POPs as a mixture. This study aims to assess the association between prenatal exposure to multiple POPs and adiposity markers and blood pressure in preadolescents. Methods: This study included 1667 mother-child pairs enrolled in the PELAGIE (France) and the INMA (Spain) mother-child cohorts. Three polychlorobiphenyls (PCB 138, 153 and 180, treated as a sum of PCBs) and three organochlorine pesticides (p,p'-Dichlorodiphenyldichloroethylene [p,p'-DDE], β-hexachlorocyclohexane [β-HCH], and hexachlorobenzene [HCB]) were assessed in maternal or cord serum. Body mass index z-score (zBMI), abdominal obesity (waist-to-height ratio > 0.5), percentage of fat mass, and blood pressure (mmHg) were measured at around 12 years of age. Single-exposure associations were studied using linear or logistic regressions, and the POP mixture effect was evaluated using quantile G-computation (qgComp) and Bayesian Kernel Machine Regression (BKMR). All models were adjusted for potential confounders and performed for boys and girls together and separately. Results: Prenatal exposure to the POP mixture was associated with higher zBMI (beta [95 % CI] of the qgComp = 0.15 [0.07; 0.24]) and percentage of fat mass (0.83 [0.31; 1.35]), with no evidence of sex-specific association. These mixture effects were also statistically significant using BKMR. These associations were driven mainly by exposure to HCB and, to a lesser extent, to β-HCH. In addition, the single-exposure models showed an association between β-HCH and p,p'-DDE and higher systolic blood pressure, especially in girls (p,p'-DDE for girls = 1.00 [0.15; 1.86]). No significant associations were found for PCBs. Conclusion: This study suggests that prenatal exposure to POPs, particularly organochlorine pesticides, remains associated with unfavorable cardiometabolic health up to the age of 12.
dc.description.sponsorship This study received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 825712 – the OBERON project, from the French Agency for Environmental Health Safety (ANSES) under grant agreement No EST19-233, and from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874583, the ATHLETE project. This publication reflects only the authors’ view, and funding agencies are not responsible for any use that may be made of the information it contains. PELAGIE cohort: This study has been funded by Inserm (since the beginning), the French Ministries of Health (2003–2004), Labor (2002–2003), and Research (ATC 2003–2004), the French National Institute for Public Health Surveillance (InVS, 2002–2006), the National Agency for Research (ANR, 2005–2008, 2010–2012, 2015–2019), the French Agency for Environmental Health Safety (Afsset/ANSES, 2007–2009, 2009–2012), the French Agency for Drug Safety (2013–2017), the Fondation de France (2014–2017, 2015–2018, 2017–2021), the French Ministry of Ecology (PNRPE 2014–2016) and the Research Institute of Public Health (IResP 2011–2014), as well as the following European programs: Hi-WATE 2007–2009, and ENRIECO 2008–2010. INMA-Gipuzkoa: This study was funded by grants from Instituto de Salud Carlos III (FIS-PI13/02187 and FIS-PI18/01142 incl. FEDER funds), CIBERESP, Department of Health of the Basque Government (2015111065), and the Provincial Government of Gipuzkoa (DFG15/221) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain). INMA-Sabadell: This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR 2009 SGR 501, and Fundació La Marató de TV3 (090430). ISGlobal acknowledges support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (2018–000806-S) and support from the Generalitat de Catalunya through the CERCA Program. INMA-Valencia: This study was funded by grants from the EU (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5–1, and H2020 No 874583, the ATHLETE project), Spain: ISCIII (G03/176; FIS-FEDER: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI17/00663 and PI19/1338; Miguel Servet-FEDER MS11/00178, MS15/00025, MS20/0006,and MS II16/00051), Generalitat Valenciana (CIAICO/2021/132), FISABIO (UGP 15–230, UGP-15–244, and UGP-15–249), and Alicia Koplowitz Foundation 2017.
dc.format.mimetype application/pdf
dc.identifier.citation Rouxel E, Costet N, Monfort C, Audouze K, Cirugeda L, Gaudreau E, Grimalt JO, Ibarluzea J, Lainé F, Llop S, Lopez-Espinosa MJ, Rouget F, Santa-Marina L, Vrijheid M, Chevrier C, Casas M, Warembourg C. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents. Environ Int. 2023 Aug;178:108056. DOI: 10.1016/j.envint.2023.108056
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2023.108056
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/58221
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Int. 2023 Aug;178:108056
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825712
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/bync-nd/4.0/
dc.subject.keyword Birth cohort
dc.subject.keyword Blood pressure
dc.subject.keyword Body mass index
dc.subject.keyword Chemicals
dc.subject.keyword Mixture
dc.subject.keyword Persistent organic pollutant
dc.title Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)