Structure and dynamics of large-scale cognitive networks in Huntington's disease
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- dc.contributor.author Aracil-Bolaños, Ignacio
- dc.contributor.author Martínez Horta, Saúl
- dc.contributor.author González de Echávarri, José Maria
- dc.contributor.author Sampedro, Frederic
- dc.contributor.author Pérez Pérez, Jesús
- dc.contributor.author Horta Barba, Andrea
- dc.contributor.author Campolongo Perillo, Antònia
- dc.contributor.author Izquierdo, Cristina
- dc.contributor.author Gómez-Ansón, Beatriz
- dc.contributor.author Pagonabarraga, Javier
- dc.contributor.author Kulisevsky, Jaime J.
- dc.date.accessioned 2022-09-15T07:13:33Z
- dc.date.available 2022-09-15T07:13:33Z
- dc.date.issued 2022
- dc.description.abstract Background: Huntington's disease is a neurodegenerative disorder characterized by clinical alterations in the motor, behavioral, and cognitive domains. However, the structure and disruptions to large-scale brain cognitive networks have not yet been established. Objective: w aimed to profile changes in large-scale cognitive networks in premanifest and symptomatic patients with Huntington's disease. Methods: we prospectively recruited premanifest and symptomatic Huntington's disease mutation carriers as well as healthy controls. Clinical and sociodemographic data were obtained from all participants, and resting-state functional connectivity data, using both time-averaged and dynamic functional connectivity, was acquired from whole-brain and cognitively oriented brain parcellations. Results: a total of 64 gene mutation carriers and 23 healthy controls were included; 21 patients with Huntington's disease were classified as premanifest and 43 as symptomatic Huntington's disease. Compared with healthy controls, patients with Huntington's disease showed decreased network connectivity within the posterior hubs of the default-mode network and the medial prefrontal cortex, changes that correlated with cognitive (t = 2.25, P = 0.01) and disease burden scores (t = -2.42, P = 0.009). The salience network showed decreased functional connectivity between insular and supramarginal cortices and also correlated with cognitive (t = 2.11, P = 0.02) and disease burden scores (t = -2.35, P = 0.01). Dynamic analyses showed that network variability was decreased for default-central executive networks, a feature already present in premanifest mutation carriers (dynamic factor 8, P = 0.02). Conclusions: Huntington's disease shows an early and widespread disruption of large-scale cognitive networks. Importantly, these changes are related to cognitive and disease burden scores, and novel dynamic functional analyses uncovered subtler network changes even in the premanifest stages.
- dc.format.mimetype application/pdf
- dc.identifier.citation Aracil-Bolaños I, Martínez-Horta S, González-de-Echávarri JM, Sampedro F, Pérez-Pérez J, Horta-Barba A, et al. Structure and dynamics of large-scale cognitive networks in Huntington's disease. Mov Disord. 2022 Feb; 37(2): 343-53. DOI: 10.1002/mds.28839
- dc.identifier.doi http://dx.doi.org/10.1002/mds.28839
- dc.identifier.issn 0885-3185
- dc.identifier.uri http://hdl.handle.net/10230/54071
- dc.language.iso eng
- dc.publisher Wiley
- dc.rights This is an open access article under the terms of the Creative Commons http://creativecommons.org/licenses/by/4.0/ Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Huntington's
- dc.subject.keyword Cognition
- dc.subject.keyword Functional MRI
- dc.title Structure and dynamics of large-scale cognitive networks in Huntington's disease
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion