Associations between bone material strength index and FRAX scores

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• dc.contributor.author Rufus-Membere, Pamela
• dc.contributor.author Anderson, Kara B.
• dc.contributor.author Holloway-Kew, Kara L.
• dc.contributor.author Kotowicz, Mark A.
• dc.contributor.author Diez-Perez, Adolfo
• dc.contributor.author Pasco, Julie A.
• dc.date.accessioned 2025-12-01T14:24:08Z
• dc.date.available 2025-12-01T14:24:08Z
• dc.date.issued 2025
• dc.date.updated 2025-12-01T14:24:08Z
• dc.description.abstract Introduction: Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. However, its ability to predict fractures is still uncertain. This study aimed to determine the association between BMSi and 10 year fracture probability, as calculated by the FRAX algorithm. Materials and methods: BMSi was measured using the OsteoProbe in 388 men (ages 40-90 yr) from the Geelong Osteoporosis Study. The probabilities for a major osteoporotic fracture (MOF) and hip fracture (HF) were calculated using the Australian FRAX tool. Hip (HF) and major osteoporotic (MOF) fracture probabilities were computed with and without the inclusion of femoral neck bone mineral density (BMD). For each participant, four 10 year probability scores were therefore generated: (i) HF-FRAXnoBMD; (ii) HF-FRAXBMD; (iii) MOF-FRAXnoBMD; (iv) MOF-FRAXBMD. Results: BMSi was negatively correlated with age (r = - 0.114, p = 0.025), no associations were detected between BMSi and femoral neck BMD (r = + 0.035, p = 0.507). BMSi was negatively correlated with HF-FRAXnoBMD (r = - 0.135, p = 0.008) and MOF-FRAXnoBMD (r = - 0.153, p = 0.003). These trends held true for HF-FRAXBMD (r = - 0.087, p = 0.094) and MOF-FRAXBMD (r = - 0.111, p = 0.034), but only the latter reached significance. Conclusion: BMSi captures the cumulative effect of clinical risk factors in the FRAX algorithm, suggesting that it could provide additional information that may be useful in predicting risk of fractures. Further studies are warranted to establish its efficacy in predicting fracture risk.
• dc.format.mimetype application/pdf
• dc.identifier.citation Rufus-Membere P, Anderson KB, Holloway-Kew KL, Kotowicz MA, Diez-Perez A, Pasco JA. Associations between bone material strength index and FRAX scores. J Bone Miner Metab. 2025 May;43(3):230-6. DOI: 10.1007/s00774-024-01575-7
• dc.identifier.doi http://dx.doi.org/10.1007/s00774-024-01575-7
• dc.identifier.issn 0914-8779
• dc.identifier.uri http://hdl.handle.net/10230/72071
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Journal of Bone and Mineral Metabolism. 2025;43(3):230-6
• dc.rights © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Bone material strength index
• dc.subject.keyword FRAX
• dc.subject.keyword Fracture
• dc.subject.keyword Impact microindentation
• dc.subject.keyword Osteoporosis
• dc.title Associations between bone material strength index and FRAX scores
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion