Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts

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• dc.contributor.author Binter, Anne-Claire
• dc.contributor.author Granés, Laura
• dc.contributor.author Bannier, Elise
• dc.contributor.author Castro, Montserrat de
• dc.contributor.author Petricola, Sami
• dc.contributor.author Fossati, Serena
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Chevrier, Cécile
• dc.contributor.author El Marroun, Hanan
• dc.contributor.author Nieuwenhuijsen, Mark J.
• dc.contributor.author Saint-Amour, Dave
• dc.contributor.author Tiemeier, Henning
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2024-07-02T06:22:22Z
• dc.date.available 2024-07-02T06:22:22Z
• dc.date.issued 2024
• dc.description.abstract Growing evidence suggests that urban environment may influence cognition and behavior in children, but the underlying pollutant and neurobiological mechanisms are unclear. We evaluated the association of built environment and urban natural space indicators during pregnancy and childhood with brain white matter microstructure in preadolescents, and examined the potential mediating role of air pollution and road-traffic noise. We used data of the Generation R Study, a population-based birth cohort in Rotterdam, the Netherlands (n = 2725; 2002-2006) for the primary analyses. Replication of the main findings was attempted on an independent neuroimaging dataset from the PELAGIE birth cohort, France (n = 95; 2002-2006). We assessed exposures to 12 built environment and 4 urban natural spaces indicators from conception up to 9 years of age. We computed 2 white matter microstructure outcomes (i.e., average of fractional anisotropy (FA) and mean diffusivity (MD) from 12 white matte tracts) from diffusion tensor imaging data. Greater distance to the nearest major green space during pregnancy was associated with higher whole-brain FA (0.001 (95%CI 0.000; 0.002) per 7 m increase), and higher land use diversity during childhood was associated with lower whole-brain MD (-0.001 (95%CI -0.002; -0.000) per 0.12-point increase), with no evidence of mediation by air pollution nor road-traffic noise. Higher percentage of transport and lower surrounding greenness during pregnancy were associated with lower whole-brain FA, and road-traffic noise mediated 19% and 52% of these associations, respectively. We found estimates in the same direction in the PELAGIE cohort, although confidence intervals were larger and included the null. This study suggests an association between urban environment and white matter microstructure, mainly through road-traffic noise, indicating that greater access to green space nearby might promote white matter development.
• dc.description.sponsorship We gratefully acknowledge the contribution of the children and parents, general practitioners, hospitals, midwives and pharmacies in Rotterdam for their participation in the Generation R Study. The Generation R Study is conducted by the Erasmus Medical Center in close collaboration with the School of Law and Faculty of Social Sciences of the Erasmus University Rotterdam, Rotterdam; the Municipal Health Service Rotterdam Area, Rotterdam; the Rotterdam Homecare Foundation, Rotterdam; and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (STAR-MDC), Rotterdam. The general design of the Generation R Study is made possible by financial support from the Erasmus Medical Center, Rotterdam; the Erasmus University Rotterdam; Netherlands Organization for Health Research and Development (ZonMw); the Netherlands Organization for Scientific Research (NWO); and the Ministry of Health, Welfare and Sport. Air pollution exposure assessment was made possible by funding from the European Community's Seventh Framework Program (Grant Agreement no. 211250, Grant Agreement no. 243406). In addition, the study was made possible by financial support from the ZonMw (Geestkracht Program 10.000.1003 and TOP 40-00812-98-11021). Supercomputing resources for neuroimaging data processing were provided by the Dutch Organization for Scientific Research (NWO, Cartesius/Snellius). Dr. El Marroun was supported by Stichting Volksbond Rotterdam, the Netherlands Organization for Scientific Research (NWO) Aspasia grant (No: 015.016.056), and the European Union's Horizon Research and Innovation Program (HappyMums, Grant Agreement No: 101057390. We are grateful to the gynecologists, obstetricians, ultra-sonographers, midwives, pediatricians, and families who participated in the PELAGIE cohort study. The PELAGIE cohort has been funded by Inserm (since the beginning), the French Ministries of Health (2003–2004), Labor (2002–2003), and Research (ATC 2003–2004), the French National Institute for Public Health Surveillance (InVS, 2002–2006), the National Agency for Research (ANR, 2005–2008, 2010–2012, 2015–2019), the French Agency for Environmental Health Safety (Afsset/ANSES, 2007–2009, 2009–2012), the French Agency for Drug Safety (2013–2017), the Fondation de France (2014–2017, 2015–2018, 2017–2021), the French Ministry of Ecology (PNRPE 2014–2016), the Research Institute of Public Health (IResP 2011–2014), and the following European programs: Hi-WATE 2007–2009, ENRIECO 2008–2010, and OBERON 2019–2023. MRI data acquisition was performed at the Neurinfo MRI research facility of the University of Rennes I. Neurinfo is granted by the European Union (FEDER), the French State, the Brittany Council, Rennes Metropole, INRIA, Inserm, and the University Hospital of Rennes. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 874583, Advancing Tools for Human Early Lifecourse Exposome research and Translation (ATHLETE). This publication reflects only the authors' view and the European Commission is not responsible for any use that may be made of the information it contains. The geocodification of the addresses and the estimation of the air pollutants of the Dutch study participants was done within the framework of a project funded by the Health Effects Institute (HEI) (Assistance Award No. R-82811201). L.G. was funded by a Rio Hortega fellowship (CM22/00011) and M.G. by a Miguel Servet II fellowship (CPII18/00018) both awarded by the Spanish Institute of Health Carlos III We acknowledge support from the European Union's Horizon 2020 research and innovation program under grant agreements No 824989 (EUCAN-Connect), and No 733206 (LifeCycle project). ISGlobal acknowledges support from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program.
• dc.format.mimetype application/pdf
• dc.identifier.citation Binter AC, Granés L, Bannier E, de Castro M, Petricola S, Fossati S, et al. Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts. Environ Pollut. 2024 Apr 1;346:123612. DOI: 10.1016/j.envpol.2024.123612
• dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2024.123612
• dc.identifier.issn 0269-7491
• dc.identifier.uri http://hdl.handle.net/10230/60626
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Pollut. 2024 Apr 1;346:123612
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/243406
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057390
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Birth cohort
• dc.subject.keyword Child development
• dc.subject.keyword Epidemiology
• dc.subject.keyword Neuroimaging
• dc.subject.keyword Urban environment
• dc.title Urban environment during pregnancy and childhood and white matter microstructure in preadolescence in two European birth cohorts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion