Evolution of tissue-specific expression of ancestral genes across vertebrates and insects

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  • dc.contributor.author Mantica, Federica
  • dc.contributor.author Iñiguez, Luis P.
  • dc.contributor.author Marquez, Yamile
  • dc.contributor.author Permanyer, Jon
  • dc.contributor.author Torres Méndez, Antonio
  • dc.contributor.author Cruz, Josefa
  • dc.contributor.author Franch-Marro, Xavier
  • dc.contributor.author Burguera, Demián
  • dc.contributor.author Martin, David
  • dc.contributor.author Irimia Martínez, Manuel
  • dc.date.accessioned 2024-04-18T13:16:24Z
  • dc.date.issued 2024
  • dc.description Inclou material suplementari: Supplementary Methods, Discussion, Figs. 1–12, Description of Supplementary Dataset content and References.
  • dc.description.abstract Regulation of gene expression is arguably the main mechanism underlying the phenotypic diversity of tissues within and between species. Here we assembled an extensive transcriptomic dataset covering 8 tissues across 20 bilaterian species and performed analyses using a symmetric phylogeny that allowed the combined and parallel investigation of gene expression evolution between vertebrates and insects. We specifically focused on widely conserved ancestral genes, identifying strong cores of pan-bilaterian tissue-specific genes and even larger groups that diverged to define vertebrate and insect tissues. Systematic inferences of tissue-specificity gains and losses show that nearly half of all ancestral genes have been recruited into tissue-specific transcriptomes. This occurred during both ancient and, especially, recent bilaterian evolution, with several gains being associated with the emergence of unique phenotypes (for example, novel cell types). Such pervasive evolution of tissue specificity was linked to gene duplication coupled with expression specialization of one of the copies, revealing an unappreciated prolonged effect of whole-genome duplications on recent vertebrate evolution.
  • dc.description.sponsorship This research was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC-StG-LS2-637591 and ERCCoG-LS2-101002275 to M.I.), by the Spanish Ministry of Economy and Competitiveness (BFU-2017-89201-P and PID2020-115040GB-I00 to M.I.) and by the ‘Centro de Excelencia Severo Ochoa 2013-2017’(SEV-2012-0208). F.M. holds a FPI fellowship associated with the grant BFU-2017-89201-P. Additional support for this research was provided by the Spanish MINECO (PGC2018-098427- B-I00 to D.M. and X.F.-M.), the Czech Science Foundation (22-21244S to M.N.), the Australian Research Council (grant DP200103219 to P.D.C. and F.T.) and the National Institutes of Health-NIAID (grant R21AI167849 to F.G.N.).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Mantica F, Iñiguez LP, Marquez Y, Permanyer J, Torres-Mendez A, Cruz J, et al. Evolution of tissue-specific expression of ancestral genes across vertebrates and insects. Nat Ecol Evol. 2024 Jun;8(6):1140-53. DOI: 10.1038/s41559-024-02398-5
  • dc.identifier.doi http://dx.doi.org/10.1038/s41559-024-02398-5
  • dc.identifier.issn 2397-334X
  • dc.identifier.uri http://hdl.handle.net/10230/59824
  • dc.language.iso eng
  • dc.publisher Nature Research
  • dc.relation.ispartof Nat Ecol Evol. 2024 Jun;8(6):1140-53
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/637591
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/101002275
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89201-P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020-115040GB-I00
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-098427-B-I00
  • dc.rights © Springer Nature Publishing AG Mantica F, Iñiguez LP, Marquez Y, Permanyer J, Torres-Mendez A, Cruz J, et al. Evolution of tissue-specific expression of ancestral genes across vertebrates and insects. Nat Ecol Evol. 2024 Apr 15. DOI: 10.1038/s41559-024-02398-5 [http://dx.doi.org/10.1038/s41559-024-02398-5]
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.keyword Gene expression profiling
  • dc.subject.keyword Sequencing
  • dc.title Evolution of tissue-specific expression of ancestral genes across vertebrates and insects
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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