CSDE1: a versatile regulator of gene expression in cancer
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- dc.contributor.author Ciocia, Annagiulia
- dc.contributor.author Mestre Farràs, Neus
- dc.contributor.author Vicent Nacht, Ignacio
- dc.contributor.author Guitart, Tanit
- dc.contributor.author Gebauer, Fátima
- dc.date.accessioned 2024-08-01T11:55:19Z
- dc.date.available 2024-08-01T11:55:19Z
- dc.date.issued 2024
- dc.description.abstract RNA-binding proteins (RBPs) have garnered significant attention in the field of cancer due to their ability to modulate diverse tumor traits. Once considered untargetable, RBPs have sparked renewed interest in drug development, particularly in the context of RNA-binding modulators of translation. This review focuses on one such modulator, the protein CSDE1, and its pivotal role in regulating cancer hallmarks. We discuss context-specific functions of CSDE1 in tumor development, its mechanisms of action, and highlight features that support its role as a molecular adaptor. Additionally, we discuss the regulation of CSDE1 itself and its potential value as biomarker and therapeutic target.
- dc.description.sponsorship Work in Gebauer lab is supported by the Spanish Ministry of Science and Innovation [PID2021-127948NB-100 funded by MCIN/AEI/10.13039/501100011033/FEDER, UE; Centro de Excelencia Severo Ochoa CEX2020-001049-S, MCIN/AEI /10.13039/501100011033]; Catalan Agency for Research and Universities [SGR-Cat-2021-01215]; Melanoma Research Alliance [Established Investigator Award 826530, https://doi.org/10.48050/pc.gr.143718].
- dc.format.mimetype application/pdf
- dc.identifier.citation Ciocia A, Mestre-Farràs N, Vicent-Nacht I, Guitart T, Gebauer F. CSDE1: a versatile regulator of gene expression in cancer. NAR Cancer. 2024 Apr 10;6(2):zcae014. DOI: 10.1093/narcan/zcae014
- dc.identifier.doi http://dx.doi.org/10.1093/narcan/zcae014
- dc.identifier.issn 2632-8674
- dc.identifier.uri http://hdl.handle.net/10230/60878
- dc.language.iso eng
- dc.publisher Oxford University Press
- dc.relation.ispartof NAR Cancer. 2024 Apr 10;6(2):zcae014
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2021-127948NB-100
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2020-001049-S
- dc.rights © The Author(s) 2024. Published by Oxford University Press on behalf of NAR Cancer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.other Expressió gènica
- dc.title CSDE1: a versatile regulator of gene expression in cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion