Relationship between respiratory microbiome and systemic inflammatory markers in COPD: A pilot study

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• dc.contributor.author Casadevall Fusté, Carme
• dc.contributor.author Quero, Sara
• dc.contributor.author Millares, Laura
• dc.contributor.author Faner, Rosa
• dc.contributor.author Cosío, Borja G.
• dc.contributor.author Peces-Barba Romero, Germán
• dc.contributor.author Castro-Acosta, Ady Angélica
• dc.contributor.author Montón, Concepción
• dc.contributor.author Palou, Alexandre
• dc.contributor.author Pascual Guàrdia, Sergi, 1979-
• dc.contributor.author Agustí García-Navarro, Àlvar
• dc.contributor.author Gea Guiral, Joaquim
• dc.contributor.author Monsó Molas, Eduard
• dc.contributor.author BIOMEPOC group
• dc.date.accessioned 2024-09-19T06:05:59Z
• dc.date.available 2024-09-19T06:05:59Z
• dc.date.issued 2024
• dc.description.abstract The respiratory microbiome may influence the development and progression of COPD by modulating local immune and inflammatory events. We aimed to investigate whether relative changes in respiratory bacterial abundance are also associated with systemic inflammation, and explore their relationship with the main clinical COPD phenotypes. Multiplex analysis of inflammatory markers and transcript eosinophil-related markers were analyzed on peripheral blood in a cohort of stable COPD patients (n = 72). Respiratory microbiome composition was analyzed by 16S rRNA microbial sequencing on spontaneous sputum. Spearman correlations were applied to test the relationship between the microbiome composition and systemic inflammation. The concentration of the plasma IL-8 showed an inverted correlation with the relative abundance of 17 bacterial genera in the whole COPD cohort. COPD patients categorized as eosinophilic showed positive relationships with blood eosinophil markers and inversely correlated with the degree of airway obstruction and the number of exacerbations during the previous year. COPD patients categorized as frequent exacerbators were enriched with the bacterial genera Pseudomonas which, in turn, was positively associated with the severity of airflow limitation and the prior year's exacerbation history. The associative relationships of the sputum microbiome with the severity of the disease emphasize the relevance of the interaction between the respiratory microbiota and systemic inflammation.
• dc.description.sponsorship This research was funded by Centro de Investigación Biomédica en Red, Área de Enfermedades Respiratorias (CIBERES), ref. CB06/06/0043 and CB06/06/1097; Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, co-funded by the European Union, grant number PI18/00934 and PI21/00785; Spanish Ministry of Economy and Competitivity, co-funded by the European Union, grant number SAF2014-54371; Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) ref: 2017SGR442 and 2021SGR-00100; Sociedad Española de Neumología y Cirugía Torácica (SEPAR), grant number 2015 and 2019; Societat Catalana de Pneumologia (SOCAP) grant number 2020 Research Grant. The funders had no role in the design, data collection, data analysis, and reporting of this study.
• dc.format.mimetype application/pdf
• dc.identifier.citation Casadevall C, Quero S, Millares L, Faner R, Cosío BG, Peces-Barba G, et al. Relationship between respiratory microbiome and systemic inflammatory markers in COPD: A pilot study. Int J Mol Sci. 2024 Aug 2;25(15):8467. DOI: 10.3390/ijms25158467
• dc.identifier.doi http://dx.doi.org/10.3390/ijms25158467
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/61156
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Mol Sci. 2024 Aug 2;25(15):8467
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-54371
• dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword COPD
• dc.subject.keyword Eosinophils
• dc.subject.keyword Frequent exacerbators
• dc.subject.keyword Respiratory microbiome
• dc.subject.keyword Systemic inflammation
• dc.title Relationship between respiratory microbiome and systemic inflammatory markers in COPD: A pilot study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion