Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
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- dc.contributor.author Casas Sanahuja, Maribel
- dc.contributor.author Martínez, David
- dc.contributor.author Kogevinas, Manolis
- dc.contributor.author García, Ana María
- dc.contributor.author Nieuwenhuijsen, Mark J.
- dc.contributor.author Vrijheid, Martine
- dc.date.accessioned 2023-11-21T12:07:42Z
- dc.date.available 2023-11-21T12:07:42Z
- dc.date.issued 2015
- dc.description.abstract Objectives. We assessed whether maternal employment during pregnancy – overall and in selected occupational sectors – is associated with birth weight, small for gestational age (SGA), term low birth weight (LBW), length of gestation, and preterm delivery in a population-based birth cohort design. Methods. We used data from >200 000 mother-child pairs enrolled in 13 European birth cohorts and compared employed versus non-employed women. Among employees, we defined groups of occupations representing the main sectors of employment for women where potential reproductive hazards are considered to be present. The comparison group comprised all other employed women not included in the occupational sector being assessed. We performed meta-analyses of cohort-specific estimates and explored heterogeneity. Results. Employees had a lower risk of preterm delivery than non-employees [adjusted odds ratio (ORadj) 0.86, 95% confidence interval (95% CI) 0.81–0.91]. Working in most of the occupational sectors studied was not associated with adverse birth outcomes. Being employed as a nurse was associated with lower risk SGA infants (ORadj 0.91, 95% CI 0.84–0.99) whereas food industry workers had an increased risk of preterm delivery (ORadj 1.50, 95% CI 1.12–2.02). There was little evidence for heterogeneity between cohorts. Conclusions. This study suggests that, overall, employment during pregnancy is associated with a reduction in the risk of preterm birth and that work in certain occupations may affect pregnancy outcomes. This exploratory study provides an important platform on which to base further prospective studies focused on the potential consequences of maternal occupational exposures during pregnancy on child development.
- dc.description.sponsorship The authors would particularly like to thank all the cohort participants for their collaboration. The authors declare no conflicts of interest. This work has received funding from the European Union’s Seventh Framework Programme under grant agreement CHICOS nº 241604 and ENRIECO nº226285.
- dc.format.mimetype application/pdf
- dc.identifier.citation Casas M, Cordier S, Martínez D, Barros H, Bonde JP, Burdorf A, et al. Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts. Scand J Work Environ Health. 2015 Jul;41(4):384-96. DOI: 10.5271/sjweh.3500
- dc.identifier.doi http://dx.doi.org/10.5271/sjweh.3500
- dc.identifier.issn 0355-3140
- dc.identifier.uri http://hdl.handle.net/10230/58349
- dc.language.iso eng
- dc.publisher NOROSH
- dc.relation.ispartof Scandinavian Journal of Work, Environment & Health. 2015 Jul;41(4):384-96
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241604
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
- dc.rights This work is licensed under a Creative Commons Attribution 4.0 International License.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Birth cohort
- dc.subject.keyword Birth weight
- dc.subject.keyword Cohort study
- dc.subject.keyword Europe
- dc.subject.keyword European birth cohort
- dc.subject.keyword Length of gestation
- dc.subject.keyword Low birth weight
- dc.subject.keyword Maternal occupation
- dc.subject.keyword Meta-analysis
- dc.subject.keyword Pregnancy
- dc.subject.keyword Preterm delivery
- dc.subject.keyword Small for gestational age
- dc.title Maternal occupation during pregnancy, birth weight, and length of gestation: combined analysis of 13 European birth cohorts
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion